Actively Recruiting
Understanding and Preventing Cortical Mechanisms of Chemotherapy-induced Peripheral Neuropathy
Led by M.D. Anderson Cancer Center · Updated on 2026-04-24
45
Participants Needed
1
Research Sites
132 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cohort 1: To track the onset and progression of a condition called chemotherapy-induced peripheral neuropathy (CIPN). Cohort 2: To track the onset and progression of a condition called chemotherapy-induced peripheral neuropathy (CIPN) and to test a certain type of experimental neuromodulation (stimulation of the brain) with a device called a closed-loop brain-computer interface (clBCI) to see if can help to prevent pain due to CIPN.
CONDITIONS
Official Title
Understanding and Preventing Cortical Mechanisms of Chemotherapy-induced Peripheral Neuropathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to understand and read English, willing to sign informed consent, and follow study rules
- ECOG Performance Status of 0 to 2
- Willing to attend imaging sessions at MD Anderson
- 18 years of age or older
- Diagnosed with breast cancer
- Receiving chemotherapy including doxorubicin, cyclophosphamide, docetaxel, or paclitaxel
- Willing to participate in therapy sessions at home (for Objective 2 participants)
You will not qualify if you...
- Taking any antipsychotic medications
- Having active central nervous system disease such as brain metastases, leptomeningeal disease, dementia, or encephalopathy
- History of bipolar disorder or schizophrenia
- Known peripheral neuropathy from causes other than chemotherapy
- History of head injury or known seizure activity
- Prior history of chemotherapy
- Patients who will be given ddAC->T chemotherapy
- Must remain on a stable medication course during chemotherapy if prescribed
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
L
Lorenzo Cohen, PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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