Unidos Contra el VPH: Screening Preference and Uptake of HPV Self-sampling Among Latinxs Along the US-Mexico Border

What this Trial Is About

Researchers are evaluating different methods for cervical cancer screening among individuals with a cervix aged 30 to 65 who have not had a Pap test in at least three years. This study compares in-home self-sampling using either a vaginal swab or urine sample with traditional in-clinic Pap smear and HPV testing. The goal is to find more accessible and comfortable screening options to improve early detection and prevention of cervical cancer, especially for those who face barriers to clinic visits. Participants are randomly assigned to one of three groups: in-home urine self-sampling, in-home vaginal swab self-sampling, or in-clinic Pap smear with HPV co-testing. Those in the self-sampling groups receive kits with instructions and prepaid mailing materials to send their samples to a lab. The in-clinic group schedules an appointment for traditional screening at a health center. The study includes surveys at enrollment and after screening to understand participant preferences and beliefs about these methods. Throughout the study, participants complete two surveys—one at the start and another after screening completion. Researchers measure the completion rate of screening within 60 days of enrollment as the primary outcome. Secondary outcomes include participant beliefs and preferences gathered from surveys. The study lasts from enrollment through the screening period, aiming to enhance access to cervical cancer screening with safety monitoring and follow-up as needed.

Unidos Contra el VPH