Actively Recruiting
UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-3 (UNITED-3)
Led by Sunnybrook Health Sciences Centre · Updated on 2025-05-15
70
Participants Needed
1
Research Sites
265 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to test whether an adaptive radiation therapy (RT), two-phase approach in participants with glioblastoma impacts local control compared to standard non-adaptive RT approach. The main questions of the study are to see how this adaptive, two-phase RT approach compares to standard RT in terms of: * Local control * Overall and progression-free survival * Patterns of failure * Toxicity, Neurological Function, and Quality of Life
CONDITIONS
Official Title
UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-3 (UNITED-3)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histopathologically confirmed glioblastoma or grade 4 astrocytoma by biopsy or surgical resection
- Clinically appropriate for long course radiation therapy with systemic treatment
- Biopsy or surgery performed within 12 weeks prior to study entry
- Adequate blood counts and organ function based on recent lab tests
- Expected survival of at least 12 weeks
- ECOG performance status of 0, 1, or 2
- Able and willing to complete quality of life questionnaires (inability will not exclude)
- Estimated glomerular filtration rate (eGFR) of 30 mL/min/1.73 m2 or higher, or approval after risk discussion if lower
- Provided written informed consent
- Accessible for treatment and follow-up
You will not qualify if you...
- Contraindications to MRI or gadolinium contrast as per screening policies
- Unable to lie flat supine for at least 30 minutes
- Unable to tolerate immobilization with head thermoplastic mask
- Weight over 140 kg or head circumference over 60 cm
- Prior therapeutic cranial radiation
- Leptomeningeal disease spread
- History of other cancers except treated non-melanoma skin cancer or solid tumors in remission for 2 or more years
- Conditions preventing protocol compliance (psychological, geographical, etc.)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N3M5
Actively Recruiting
Research Team
J
Jay Detsky, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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