Actively Recruiting
University of Iowa Interventional Psychiatry Service Patient Registry for Treatment-Resistant Depression and Obsessive-Compulsive Disorder
Led by Mark Niciu · Updated on 2026-03-03
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to explore the effects of several interventional and procedural therapies for treatment-resistant depression TRD and Obsessive-Compulsive Disorder OCD. The study focuses on treatments including electroconvulsive therapy ECT, transcranial magnetic stimulation TMS, intravenous ketamine infusions, and intranasal esketamine insufflations. Researchers seek to identify biomarkers related to depression and treatment response to help personalize therapy for individual patients. This includes neurobehavioral testing, brain imaging, electroencephalography, cognitive and vocal assessments, genetic tests, and measures of the autonomic nervous system. Participants referred to the University of Iowas Interventional Psychiatry Clinic will be clinically evaluated and, if appropriate, begin a course of procedural treatment. Treatments studied include ECT and TMS for major depressive episodes, ketamine infusions, esketamine nasal sprays, and deep TMS for OCD. The study collects data before, during, and after treatment to compare responses across these different methods and to improve understanding of how brain function changes with therapy. During the study, participants will undergo various assessments such as the Montgomery-sberg Depression Rating Scale, Yale-Brown Obsessive Compulsive Scale, and other clinical and cognitive evaluations before starting treatment and after completing the course, usually about 4 to 6 weeks later. Researchers will also collect and analyze diverse biological and behavioral data. The study is ongoing with long-term observation possible, aiming to build a database that supports future research and personalized treatment strategies for depression and OCD.
CONDITIONS
Brief Title
University of Iowa Interventional Psychiatry Service Patient Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 to 99 years of age
- Able to understand and speak English to consent to treatment and research procedures
- Clinical diagnosis of a major depressive episode in major depressive disorder, bipolar disorder, or treatment-resistant OCD
- Evaluated as an appropriate candidate for procedural treatment by the Interventional Psychiatry Service
You will not qualify if you...
- Younger than 18 years
- Primary neuropsychiatric diagnosis other than major depressive disorder or bipolar disorder
- Serious, unstable medical problems such as uncontrolled asthma, active cancer, or major organ diseases
- Currently involuntarily committed to a psychiatric inpatient unit
- Presence of implanted devices incompatible with MRI (e.g., pacemaker, coronary stent, defibrillator, neurostimulation device)
- Presence of ferromagnetic objects in the body (bullets, shrapnel, metal slivers)
- Clinically significant claustrophobia or hearing loss
- Pregnant or nursing women or women of childbearing potential not using approved contraception
- Medical illnesses likely to alter brain structure or function, even if controlled by medication (e.g., hypertension, diabetes)
Research Team
K
Karin Nielsen, MS
E
Emerson Buse, BA
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