Actively Recruiting
University of Iowa Interventional Psychiatry Service Patient Registry
Led by Mark Niciu · Updated on 2026-03-03
1000
Participants Needed
1
Research Sites
1552 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or biomarkers, of a depressed individuals' state before, during, and/or after these treatments. Such biomarkers include neurobehavioral testing, neuroimaging, electroencephalography, cognitive testing, vocal recordings, epi/genetic testing, and autonomic nervous system measures (i.e. "fight-or-flight" response). The results obtained from this study may provide novel antidepressant treatment response biomarkers, with the future goal of targeting a given treatment to an individual patient ("personalized medicine").
CONDITIONS
Official Title
University of Iowa Interventional Psychiatry Service Patient Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18-99 years of age
- English speaker able to understand and agree to treatment and research procedures
- Clinical diagnosis of major depressive episode in major depressive disorder, bipolar disorder, or treatment-resistant OCD and candidate for treatment by the Interventional Psychiatry Service
You will not qualify if you...
- Under 18 years of age
- Primary diagnosis other than major depressive disorder or bipolar disorder
- Serious, unstable medical conditions such as hepatic, renal, respiratory, cardiovascular, endocrinologic, neurologic, immunologic, or hematologic disease
- Involuntary commitment to psychiatric inpatient units
- Presence of MRI exclusion criteria including non-MRI-compatible implanted devices, ferromagnetic objects in the body, significant claustrophobia or hearing loss
- Pregnant or nursing women or women of childbearing potential not using accepted contraception
- Medical illnesses likely to alter brain structure or function such as hypertension or diabetes even if controlled by medication
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Iowa Health Care
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
K
Karin Nielsen, MS
CONTACT
E
Emerson Buse, BA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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