Predicting Growth of Small Unruptured Intracranial Aneurysms Using Vessel Wall Imaging A Multicenter Prospective Study with 3-Year Follow-Up

What this Trial Is About

Researchers are studying unruptured intracranial aneurysms UIA sized between 3 and 7 mm to better understand how these aneurysms may change or grow over time. This observational study aims to evaluate the predictive value of arterial wall enhancement AWE seen on MRI scans as a marker for aneurysm wall instability and possible growth. The goal is to develop better tools for predicting aneurysm evolution and to improve personalized follow-up care for patients with UIA. Participants with unruptured, asymptomatic, and untreated aneurysms at bifurcation sites will be followed without occlusion treatment. Extensive clinical, biological, and imaging data will be collected over a three-year follow-up period, with visits scheduled at 1 year and 3 years after enrollment. The study will use expert neuroradiologists to assess aneurysm growth and wall enhancement on MR imaging. During the study, participants will undergo clinical and imaging evaluations at the specified visits to monitor aneurysm changes. Researchers will measure the predictive value of wall enhancement for aneurysm growth at 1, 3, and 5 years. Quality of life, genetic and biological factors, and incidence of aneurysm growth or rupture will also be assessed. This long-term observation aims to inform safe and effective follow-up strategies for people living with UIA.

Unruptured Cerebral Aneurysm: Prediction of Evolution