Actively Recruiting
Unruptured Cerebral Aneurysm: Prediction of Evolution
Led by Nantes University Hospital · Updated on 2026-04-13
1000
Participants Needed
21
Research Sites
603 weeks
Total Duration
On this page
Sponsors
N
Nantes University Hospital
Lead Sponsor
C
Centre Hospitalier St Anne
Collaborating Sponsor
AI-Summary
What this Trial Is About
The protocol has many assets. A prospective nationwide recruitment allows for the inclusion of a large cohort of patients with UIA. It will combine accurate clinical phenotyping and comprehensive imaging with CAWE screening. Besides, it will enable to exploit metadata and to explore new pathophysiological pathways of interest by crossing clinical, genetic, biological, and imaging information.
CONDITIONS
Official Title
Unruptured Cerebral Aneurysm: Prediction of Evolution
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have an unruptured, asymptomatic, untreated intracranial aneurysm at a blood vessel bifurcation measuring between 3 and 7 mm on MRI, CTA, or DSA
- Be able to participate in follow-up visits for 3 years as agreed by a multidisciplinary team
- Be 18 years of age or older
You will not qualify if you...
- Unable to give informed consent
- Contraindications to MRI such as having a heart pacemaker, metal foreign body in the eye, brain aneurysm clip, or severe claustrophobia
- Contraindications to gadolinium contrast including low kidney function (eGFR below 30 mL/min/1.73 m2), history of nephrogenic systemic fibrosis, allergic reaction to gadolinium contrast, worsening kidney function, pregnancy or breastfeeding
- Having a mycotic, fusiform-shaped, dissecting aneurysm or aneurysm related to an arteriovenous malformation
- Family history of polycystic kidney disease, Ehlers-Danlos syndrome, Marfan's syndrome, fibromuscular dysplasia, or Moya Moya disease
- Aneurysm located inside the cavernous sinus preventing reliable wall enhancement assessment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 21 locations
1
Clairval's Hospital
Marseille, Bouches-du-Rhône, France, 13000
Actively Recruiting
2
Brest University Hospital
Brest, Finistère, France, 29200
Actively Recruiting
3
Bordeaux University Hospital
Bordeaux, Gironde, France, 33000
Actively Recruiting
4
Toulouse University Hospital
Toulouse, Haute-Garonne, France, 31000
Actively Recruiting
5
Limoges University Hospital
Limoges, Haute-Vienne, France, 87000
Actively Recruiting
6
Rennes University Hospital
Rennes, Ille-et-Vilaine, France, 35000
Actively Recruiting
7
Tours University Hospital
Tours, Indre-et-Loire, France, 37000
Actively Recruiting
8
Nantes University Hospital
Nantes, Loire-Atlantique, France, 44000
Actively Recruiting
9
Angers University Hospital
Angers, Maine et Loire, France, 49000
Actively Recruiting
10
Reims University Hospital
Reims, Marne, France, 51100
Not Yet Recruiting
11
Nancy University Hospital
Nancy, Meurthe-et-Moselle, France, 54000
Actively Recruiting
12
AP-HP La Pitié-Salpêtrière Hospital
Paris, Paris, France, 75000
Actively Recruiting
13
AP-HP Le Kremlin Bicêtre Hospital
Paris, Paris, France, 75000
Actively Recruiting
14
Rostchild Foundation Hospital
Paris, Paris, France, 75000
Actively Recruiting
15
Rouen University Hospital
Rouen, Seine-Maritime, France, 76000
Actively Recruiting
16
Amiens University Hospital
Amiens, Somme, France, 80000
Actively Recruiting
17
Creteil University Hospital
Créteil, Val-de-Marne, France, 94000
Not Yet Recruiting
18
St Anne HIA
Toulon, France
Actively Recruiting
19
Ste Anne's Hospital
Paris, Île-de-France Region, France, 75674
Actively Recruiting
20
UMC Utrecht
Utrecht, Netherlands, 3500
Actively Recruiting
21
InselHospital Bern
Bern, Switzerland, 3000
Not Yet Recruiting
Research Team
R
Romain BOURCIER, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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