Actively Recruiting
Unveiling the Neural Mechanisms of 5-HT7 in Sleep Apnea Induced by Arousal Dysregulation
Led by Beijing Tsinghua Chang Gung Hospital · Updated on 2024-09-26
140
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Obstructive sleep apnea (OSA), recognized as a highly prevalent sleep breathing disorder with severe complications, features a complex etiology. Poor understanding of disease pathogenesis limits the overall efficacy of interventions. Studies have found that upregulation of 5-HT7 expression in the lateral hypothalamus (LH) could reduce arousal threshold (ArTH) and induce an inhibitory effect to the respiratory central, which was associated with hypoxic stimulation. Therefore, the investigators speculate that the structural/functional abnormalities of the arousal-respiratory neural circuit, mediated by LH5-HT7, may play an important role in the pathogenesis of OSA. To verify the hypothesis, the investigators will compare the ArTH and the brain network presenting by multimodal MRI in normal individuals, snoring individuals, and OSA patients, to reveal the correlation between arousal dysregulation and the structure/function of LH regions; compare the changes of ArTH and brain network in OSA patients with low ArTH before and after CPAP treatment, to verify the interaction between hypoxia and arousal dysregulation, as well as whether the damaging performance of the arousal-respiratory brain regulation area in OSA patients can be partially reversed by relieving hypoxia. Above all, the joint application B team will further analyze the LH5-HT7 neural mechanism in the pathogenesis of OSA.
CONDITIONS
Official Title
Unveiling the Neural Mechanisms of 5-HT7 in Sleep Apnea Induced by Arousal Dysregulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 20 and 60 years
- For OSA patients: symptoms of sleep snoring and daytime sleepiness and confirmed OSA diagnosis by overnight sleep monitoring
- For simple snorers: symptoms of sleep snoring and no OSA diagnosis by overnight sleep monitoring
- For healthy controls: no symptoms of sleep snoring and no OSA diagnosis by overnight sleep monitoring
You will not qualify if you...
- Severe pulmonary, neurological, or cardiovascular complications
- History of long-term non-invasive positive pressure ventilation treatment (more than 3 months) or upper airway surgery
- Sleep-disordered breathing due to special causes such as hypothyroidism, acromegaly, or vocal cord paralysis
- Severe mental illness, long-term alcohol abuse, or prolonged use of sedative-hypnotic drugs
- Central sleep apnea predominant sleep disorders
- Severe craniofacial deformities, myasthenia gravis, or other known muscle diseases
- Peripheral neuropathy caused by diabetes, autoimmune diseases, or similar
- Comorbid insomnia, anxiety, depression, or other sleep disorders
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
No. 168 Litang Road, Changping District
Beijing, Beijing Municipality, China, 100028
Actively Recruiting
Research Team
Y
Yingqian Zhou
CONTACT
Y
Yue Yin
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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