Actively Recruiting
UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF
Led by David Lanfear · Updated on 2026-05-07
10
Participants Needed
1
Research Sites
61 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will use polygenic scores, a tool which describes differences in genetics, to examine effectiveness of beta blocker medication in heart failure patients with ejection fraction of 41-50 percent. The study will also assess beta blockers' effect on the changes in left ventricular end-systolic volume index by MRI.
CONDITIONS
Official Title
UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-89 years
- Ejection Fraction (EF) >40% and <=50% by any test within 1 year (most recent required)
- Clinical diagnosis of heart failure within 1 year, shown by hospital discharge with HF diagnosis, emergency room discharge for HF, outpatient HF diagnosis with diuretic use, or elevated BNP/NTproBNP levels
- Ability to fully participate in study activities without long travel limitations
You will not qualify if you...
- Unable to provide informed consent
- Previous ejection fraction <=35%
- Currently taking beta blockers at or above 25% of the target dose
- Uncontrolled high blood pressure (systolic >180 at enrollment)
- Contraindications to all beta blockers or intolerance to metoprolol
- Low blood pressure (systolic <100) or heart rate <70
- Active cancer treatment
- History of heart transplant or left ventricular assist device or expected within one year
- Life expectancy less than 1 year
- Dialysis dependence or end-stage renal disease
- Recent (within 90 days) or planned heart attack, PCI, or cardiac surgery
- Absolute need for beta blockers for other reasons besides heart failure
- Contraindication to MRI procedures
- Investigator decision that participation is not in patient's best interest
AI-Screening
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Trial Site Locations
Total: 1 location
1
Henry Ford Health
Detroit, Michigan, United States, 48202
Actively Recruiting
Research Team
W
Whitney Cabral, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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