Actively Recruiting
Upfront EUS CGN/CPN vs Conventional Step up Approach for Inoperable Painful Pancreatic Cancer
Led by Chinese University of Hong Kong · Updated on 2026-05-06
94
Participants Needed
1
Research Sites
246 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with unresectable pancreatic cancer are often demoralized by intractable, persistent and incapacitating pain. It must be managed aggressively and strong opioids are recommended as the mainstay of treatment. However, patients develop opioid-related adverse effects. EUS-guided celiac plexus neurolysis (CPN) and celiac ganglion neurolysis (CGN) has been shown to provide high efficacy for pain control. The optimal timing, however, is in debate.
CONDITIONS
Official Title
Upfront EUS CGN/CPN vs Conventional Step up Approach for Inoperable Painful Pancreatic Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �3 18 years old
- Diagnosed to have inoperable pancreatic cancer
- Presence of tumor pain (centrally located, constant, with no other obvious cause) with a VAS �3 3
- Karnofsky performance status �3 60
- Planned for EUS examination and/or biopsy of the pancreatic tumor
You will not qualify if you...
- Allergy to bupivacaine or alcohol
- Potentially operable after neoadjuvant therapy
- Expected survival of less than 3 months
- Already on opioids for pain control
- Previous percutaneous or EUS-guided CGN/CPN
- Recurrent pancreatic tumors after operation
- Uncorrectable coagulopathy
- Inability or unwillingness to provide informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Prince of Wales Hospital
Hong Kong, Hong Kong, Hong Kong, 00000
Actively Recruiting
Research Team
S
Shannon Melissa Chan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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