Surgical Approach Using Upfront Targeted Axillary Dissection in Women with Early Luminal Breast Cancer and Limited Lymph Node Spread

What this Trial Is About

This research aims to reduce the need for axillary lymph node dissection ALND in women with luminal breast cancer who have limited axillary involvement detected by ultrasound and confirmed by needle biopsy. It focuses on patients with 1 or 2 suspicious lymph nodes and who are not recommended for neoadjuvant treatment. The study follows criteria from the latest NCCN guidelines for managing these patients. Participants will undergo upfront targeted axillary dissection UTAD, where marked suspicious lymph nodes and sentinel lymph nodes are surgically removed and examined. ALND will only be performed if three or more sentinel lymph nodes are found positive, aiming to limit overtreatment. The surgery uses reflector localization and a gamma probe to accurately identify lymph nodes. During the study, participants will be assessed for the successful removal of the targeted lymph nodes and monitored to prevent unnecessary ALND. Follow-up will include tracking axillary recurrence over five years after surgery. Patients will be evaluated for adherence to procedures and availability for long-term follow-up throughout the study duration.

Upfront Targeted Axillary Dissection for Luminal Breast Cancer With Limited Axillary Involvement