Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT05806645

UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events

Led by University of Alberta · Updated on 2026-04-07

6046

Participants Needed

2

Research Sites

237 weeks

Total Duration

On this page

Sponsors

U

University of Alberta

Lead Sponsor

A

Alberta Health services

Collaborating Sponsor

AI-Summary

What this Trial Is About

Nearly one in ten people who are hospitalized in Canada develop a complication with sudden loss of kidney function, called acute kidney injury (AKI). AKI may lead to other severe health problems after discharge home, such as kidney failure requiring dialysis treatment, heart failure, heart attacks, stroke, and even premature death. Discharge from hospital to home can be a difficult transition where there are often gaps in identification, communication, care coordination, education, and planning of care for AKI. The study team will co-design and evaluate a tailored post-discharge care plan that is based on the risk of later kidney problems and uses currently available, yet untapped digital innovation to improve the health and experience of people with AKI. This study will be built into Alberta's new Epic Systems based provincial electronic health record (EHR). The plan is to use digital tools in the EHR to identify all people in Alberta hospitals that have had an AKI event and are at increased risk of long-term complications. Half will randomly be assigned to receive a tailored care plan based on their risk at hospital discharge while the other half will receive care as it is currently provided by their healthcare team. The electronic health system will automatically calculate a patient's risk and report this risk in their chart along with recommendations for care. The study team includes patients, healthcare providers, and health system decision makers needed to co-develop the proposed strategy and introduce the changes needed to deliver this intervention. The investigators will study whether this strategy can reduce health problems that may happen after AKI including death, chronic kidney disease (CKD), kidney failure, heart attacks, and stroke. The investigators will also determine if the approach improves patient experience during the transition from hospital to home. This study has the potential to revolutionize how we care for people that leave hospital after having AKI.

CONDITIONS

Official Title

UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Hospitalized at a site using Alberta Health Services electronic health record
  • Acute Kidney Injury (Stage 1-3) identified during hospital stay per KDIGO guidelines
Not Eligible

You will not qualify if you...

  • Advanced chronic kidney disease before hospitalization (eGFR less than 30 mL/min/1.73m2)
  • Receiving dialysis before hospitalization
  • Very low risk (less than 1%) of advanced chronic kidney disease
  • Not a resident of Alberta
  • Receiving palliative care
  • Currently enrolled in the UPTAKE VC Trial
  • Admitted under a nephrologist at discharge
  • Dialysis for at least 2 days in the week before discharge
  • Receiving apheresis treatment
  • Kidney transplant recipient
  • Diagnosis of glomerulonephritis
  • Cirrhosis with complications such as ascites, varices, hepatic encephalopathy, or hepatorenal syndrome

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 2 locations

1

Foothills Medical Centre

Calgary, Alberta, Canada

Actively Recruiting

2

University of Alberta Hospital

Edmonton, Alberta, Canada

Actively Recruiting

Loading map...

Research Team

N

Neesh Pannu

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

HEALTH_SERVICES_RESEARCH

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here