Actively Recruiting
UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events
Led by University of Alberta · Updated on 2026-04-07
6046
Participants Needed
2
Research Sites
237 weeks
Total Duration
On this page
Sponsors
U
University of Alberta
Lead Sponsor
A
Alberta Health services
Collaborating Sponsor
AI-Summary
What this Trial Is About
Nearly one in ten people who are hospitalized in Canada develop a complication with sudden loss of kidney function, called acute kidney injury (AKI). AKI may lead to other severe health problems after discharge home, such as kidney failure requiring dialysis treatment, heart failure, heart attacks, stroke, and even premature death. Discharge from hospital to home can be a difficult transition where there are often gaps in identification, communication, care coordination, education, and planning of care for AKI. The study team will co-design and evaluate a tailored post-discharge care plan that is based on the risk of later kidney problems and uses currently available, yet untapped digital innovation to improve the health and experience of people with AKI. This study will be built into Alberta's new Epic Systems based provincial electronic health record (EHR). The plan is to use digital tools in the EHR to identify all people in Alberta hospitals that have had an AKI event and are at increased risk of long-term complications. Half will randomly be assigned to receive a tailored care plan based on their risk at hospital discharge while the other half will receive care as it is currently provided by their healthcare team. The electronic health system will automatically calculate a patient's risk and report this risk in their chart along with recommendations for care. The study team includes patients, healthcare providers, and health system decision makers needed to co-develop the proposed strategy and introduce the changes needed to deliver this intervention. The investigators will study whether this strategy can reduce health problems that may happen after AKI including death, chronic kidney disease (CKD), kidney failure, heart attacks, and stroke. The investigators will also determine if the approach improves patient experience during the transition from hospital to home. This study has the potential to revolutionize how we care for people that leave hospital after having AKI.
CONDITIONS
Official Title
UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Hospitalized at a site using Alberta Health Services electronic health record
- Acute Kidney Injury (Stage 1-3) identified during hospital stay per KDIGO guidelines
You will not qualify if you...
- Advanced chronic kidney disease before hospitalization (eGFR less than 30 mL/min/1.73m2)
- Receiving dialysis before hospitalization
- Very low risk (less than 1%) of advanced chronic kidney disease
- Not a resident of Alberta
- Receiving palliative care
- Currently enrolled in the UPTAKE VC Trial
- Admitted under a nephrologist at discharge
- Dialysis for at least 2 days in the week before discharge
- Receiving apheresis treatment
- Kidney transplant recipient
- Diagnosis of glomerulonephritis
- Cirrhosis with complications such as ascites, varices, hepatic encephalopathy, or hepatorenal syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Foothills Medical Centre
Calgary, Alberta, Canada
Actively Recruiting
2
University of Alberta Hospital
Edmonton, Alberta, Canada
Actively Recruiting
Research Team
N
Neesh Pannu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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