Bladder outlet resistance.
Ries Kranse, Ron van Mastrigt
https://pubmed.ncbi.nlm.nih.gov/12576832Actively Recruiting
Age: 18Years - 80Years
MALE
Healthy Volunteers
ID07403786
Urethral Resistive Index (URI): A New Uroflowmetric Parameter in the Non-Invasive Diagnosis of Urethral Obstruction
Led by Ankara City Hospital Bilkent · Updated on 2026-04-06
60
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a new, non-invasive diagnostic method called the Urethral Resistive Index (URI) to detect urethral stricture in men. This observational study aims to see if URI can accurately diagnose urethral obstruction without needing invasive procedures like surgery or pressure-flow studies. The study involves men aged 18 to 80 years, including those with suspected urethral stricture and healthy volunteers, to compare results and validate the new parameter. Participants will undergo two uroflowmetry tests: a standard natural voiding test followed by a forced voiding session using the Valsalva maneuver. The URI is calculated by comparing the maximum flow rates from these two sessions. The study includes 30 men with confirmed urethral stricture scheduled for surgery and 30 healthy male volunteers without urinary symptoms. Data collection occurs at a specialized urology clinic. During the study, researchers will gather clinical and uroflowmetric data, including the URI measured at baseline during the uroflowmetry sessions. They will analyze the diagnostic accuracy of URI using statistical methods to find the best cut-off value for detecting urethral stricture. The study also assesses symptom scores and monitors participants for any discomfort during testing. The total participation period varies but focuses on these two uroflowmetry assessments.
CONDITIONS
Brief Title
Urethral Resistive Index (URI): A New Parameter for Diagnosing Urethral Obstruction
Who Can Participate
Age: 18Years - 80Years
MALE
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Male participants aged between 18 and 80 years
- Patients scheduled for urethral surgery due to suspected urethral stricture confirmed during surgery
- Healthy male volunteers without lower urinary tract symptoms
- Voluntary signing of the Informed Consent Form
You will not qualify if you...
- Voiding volume less than 150 mL
- Causes of obstruction other than urethral stricture, such as Benign Prostatic Hyperplasia (BPH)
- Diagnosis of neurogenic bladder dysfunction or history of neurological disease affecting bladder function
- Presence of severe comorbidities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo natural and forced uroflowmetry tests to calculate the Urethral Resistive Index (URI), a non-invasive parameter for diagnosing urethral obstruction.
1 visit (in-person)
Long-term Monitoring
Duration - Up to study completion
Participants are observed to evaluate the diagnostic performance of the URI and its correlation with clinical symptom scores.
Additional assessments may occur depending on clinical evaluation
Trial Site Locations
Total: 1 location
1
Ankara Bilkent City Hospital
Ankara, Universiteler, Turkey (Türkiye), 06800
Actively Recruiting
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Research Team
Y
Yusuf Gökkurt
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Flow resistive forces index (QRF): Development and clinical applicability assessment of a novel measure of bladder outlet resistance, aiming to enhance the diagnostic performance of uroflowmetry.
Evangelos Spyropoulos, Ioannis Galanakis, Dimitrios Deligiannis...
https://pubmed.ncbi.nlm.nih.gov/31999073Evaluation of non-invasive tests as diagnostic tools in assessment of bladder outlet obstruction severity in men with anterior urethral stricture.
Jakub Krukowski, Adam Kałużny, Jakub Kłącz...
https://pubmed.ncbi.nlm.nih.gov/34729232