Actively Recruiting
Urinary Creatinine Excretion Time in the Neonatal Period
Led by Central Hospital, Nancy, France · Updated on 2025-02-19
40
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Newborn's renal function is difficult to assess and its physiology during the first days of life is still incompletely known. Studies suggest that the newborn almost completely reabsorbs creatinine during the first 48 to 72 hours of life, while at the same time it continues to produce its own creatinine. Therefore, the initial stock of creatinine at birth still increases through this production and the non or weak clearance. A better knowledge of renal physiopathology in newborns would allow to improve the therapeutic management of the infants, particularly in case of potential nephrotoxicity. No study has attempted to assess the increase in urinary creatinine excretion in neonates from a given time. Objectives: To show when urinary creatinine excretion in newborns is efficient. Results: this study mightr show an inflection point in urinary creatinine excretion illustrating the postnatal age when renal function becomes efficient.
CONDITIONS
Official Title
Urinary Creatinine Excretion Time in the Neonatal Period
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Full-term newborns (37 weeks of gestation or more)
- Born from a normal and spontaneous pregnancy
- Good neonatal adaptation (Apgar score of 7 or more at 5 minutes of life)
- Normal weight between the 10th and 90th percentile
You will not qualify if you...
- Newborns without interpretable urine samples
- Newborns with significant clinical or biological abnormalities
- Neonates with hemodynamic disorders such as low blood pressure or signs of dehydration within the first 3 days of life
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Maternite Regionale Universitaire CHRU NANCY
Nancy, Lorraine, France, 54035
Actively Recruiting
Research Team
J
Jean-Michel HASCOET
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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