Actively Recruiting
Urinary Microbiome Changes Following Administration of 500 mg of NDS-446 in Women With Dry OAB at 12 Weeks
Led by Loyola University · Updated on 2025-09-09
40
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to learn about how the use of 500 mg of dried cranberry powder extract (NDS-446) changes the bacteria that normal reside in the bladder of women who don't have urinary leakage problems but do have problems with urinary urgency and frequency.
CONDITIONS
Official Title
Urinary Microbiome Changes Following Administration of 500 mg of NDS-446 in Women With Dry OAB at 12 Weeks
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female aged 18 to 99 years, ambulatory
- Overactive bladder symptoms lasting more than 6 months
- Voiding frequency greater than 8 times in 24 hours
- More than 3 episodes of urgency (grade 3 or 4) without incontinence during a 3-day diary at baseline
You will not qualify if you...
- More than 3 episodes of urinary incontinence in the past month
- More than 3 urinary tract infections in the last 12 months
- Diagnosis of painful bladder syndrome or interstitial cystitis
- Lower urinary tract surgery within the past 6 months
- Drug or non-drug treatment for overactive bladder in the past 60 days
- Current medications affecting detrusor muscle activity
- Use of Warfarin
- Failure to complete a 3-day urinary diary
- Daily Aspirin dose over 81 mg
- Gross blood in urine
- Allergy or sensitivity to aspirin
- Use of anti-platelet agents
- Inability to swallow capsules
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Loyola Medical Center
Maywood, Illinois, United States, 60153
Actively Recruiting
Research Team
M
Mary Tulke, RN
CONTACT
E
Elizabeth Mueller, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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