Actively Recruiting
Urinary Proteomic Assessment of Ovarian Malignancy and Disease Progression
Led by Xiangya Hospital of Central South University · Updated on 2025-01-07
240
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers aim to study urinary proteins in women with and without ovarian cancer to better understand differences in protein composition. This observational study focuses on whether these differences can help diagnose ovarian cancer, relate to tumor burden, and assist in monitoring the disease over time. Female patients admitted to the gynecological ward for surgical treatment who are initially diagnosed with pelvic masses, malignant ascites, ovarian cysts, hydrosalpinx, uterine fibroids, or uterine adenomyosis are considered for participation. The study involves collecting urine samples to analyze protein markers and comparing protein profiles between those with ovarian cancer and those with non-malignant gynecological diseases. Participants will provide urine samples for proteomic analysis and undergo pathological diagnosis from enrollment until surgery or biopsy within one week. The study monitors urinary protein markers to assess their association with tumor burden and potential for disease surveillance. Participation involves signing informed consent and meeting study criteria, with ongoing evaluation to ensure sample quality and participant safety throughout the study period.
CONDITIONS
Official Title
Urinary Proteomic Assessment of Ovarian Malignancy and Disease Progression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients in the gynecological ward for surgical treatment.
- Initial diagnosis of "pelvic mass" or "malignant ascites" may be considered as ovarian cancer; Or the initial diagnosis of "ovarian cyst", "hydrosalpinx", "uterine fibroids" or "uterine adenomyosis" are considered as gynecological non-malignant diseases.
- Over 18 years of age.
- Voluntary participation and signing of informed consent.
You will not qualify if you...
- Study participants with a prior history of malignant tumors.
- Study participants with prior chronic kidney disease or renal insufficiency.
- Study participants who have received or are receiving treatment for primary disease.
- Study participants whose pathological diagnosis was not clear.
- Study participants who withdraw informed consent and request withdrawal.
- Study participants unable to provide a qualified urine sample.
- Situations in which the researcher considers it necessary to withdraw from the study.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Xiangya Hosipital of Central South University
Changsha, Hunan, China, 410008
Actively Recruiting
Research Team
Y
Yu Zhang, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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