Actively Recruiting
Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure
Led by Lakeland Regional Health Systems, Inc. · Updated on 2026-04-09
600
Participants Needed
1
Research Sites
74 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care. The main questions it aims to answer are: 1. Does targeting a higher urine sodium goal achieve greater natriuresis and diuresis? 2. Does targeting a higher urine sodium goal reduce frequency of hospital readmissions? 3. Does targeting a higher urine sodium goal reduce hospital length of stay? Researchers will compare natriuresis-guided arms with standard of care to see if targeting higher natriuresis goals improves significantly over current practice. Participants will submit urine samples at routine intervals after being given diuretics to evaluate urine sodium concentration. If urine sodium is low then diuretic dose will be increased.
CONDITIONS
Official Title
Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years of age or older admitted to Lakeland Regional Medical Center
- Primary diagnosis of acute decompensated heart failure
- At least one sign of excess fluid such as bilateral lower leg swelling, jugular vein distension, hepatojugular reflex, lung crackles, or chest x-ray showing fluid in lungs or pleural effusions
You will not qualify if you...
- Admission to the intensive care unit
- Presence of ST-elevated myocardial infarction
- Presence of type 1 non-ST elevated myocardial infarction
- Shortness of breath mainly due to a non-cardiac cause as judged by doctors
- Use of supplemental oxygen at 3 liters per minute or more at baseline
- No urine output (anuria)
- End-stage kidney disease according to KDIGO criteria
- Use of dialysis
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Lakeland Regional Hospital
Lakeland, Florida, United States, 33805
Actively Recruiting
Research Team
A
Andrew Lurie, DO
CONTACT
A
Anas Bizanti, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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