Actively Recruiting
Use of [18F] Fluoroethyl-L-tyrosine PET/MRI for Identifying Small Functional Pituitary Adenomas
Led by Mayo Clinic · Updated on 2026-03-09
5
Participants Needed
1
Research Sites
46 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research is to evaluate the diagnostic role and clinical efficacy of investigational FET-PET/MRI in detecting MRI-occult primary or residual/recurrent functional pituitary adenomas (PAs) and its influence on clinical and surgical decisions.
CONDITIONS
Official Title
Use of [18F] Fluoroethyl-L-tyrosine PET/MRI for Identifying Small Functional Pituitary Adenomas
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 to 75 years of age with biochemically proven Cushing's Disease, Acromegaly, or tumor hyperprolactinemia according to current Endocrinology guidelines
- Clinical DCE-MRI protocol that is negative or equivocal for identifiable tumor
- Patient willing to have surgery if lesion found, or already scheduled for surgery and lesion identification would be helpful
- Able to provide informed consent and complete the imaging protocols
- Female subjects of childbearing potential must have a negative urine pregnancy test within 48 hours prior to the 18F-FET injection
You will not qualify if you...
- Patients with contraindications to MRI or PET scans
- Patients with known allergies to contrast agents or other imaging-related materials
- Patients with severe medical conditions that prevent participation, such as inability to lie still for 30-60 minutes
- Patients with successful MRI localization of the adenoma
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Jacksonville, Florida, United States, 32224
Actively Recruiting
Research Team
J
Julia Santos
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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