Actively Recruiting
Use of Cinnamomum Verum for Induction of Labor. Double Blind Randomized Clinical Trial
Led by Universidad Nacional Autonoma de Honduras · Updated on 2025-12-04
70
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the research protocol is to evaluate the effectiveness of Cinnamomum verum extract for the initiation of labor. Cinnamaldehyde ((E)-3-Phenylprop-2-enal) is an α, β unsaturated aromatic aldehyde, derived from cinnamon (Cinnamomum Verum oil) used as a flavoring; It is a clear yellowish liquid substance, with a strong odor and flavor. It is the main component of cinnamon (63%), giving it its physicochemical properties. Cinnamon has been an element of empirical use for the beginning of labor, however, its effectiveness has not been demonstrated. Cinnamon has been reported for its ethnopharmacological properties in pregnancy, being used to facilitate childbirth, as a lactagogue and for postpartum recovery. In Honduras, its use has been reported to relieve nausea and vomiting during pregnancy, to reduce abdominal pain. , reduction of lower limb edema, to relieve anxiety during labor, as well as a lactagogue without convergent opinions.
CONDITIONS
Official Title
Use of Cinnamomum Verum for Induction of Labor. Double Blind Randomized Clinical Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent provided by patient and guardian
- Willingness to comply with all study procedures and availability during study
- Ability and willingness to participate in study
- Patients under 18 years of age
- Full-term pregnancy between 37 and 41 weeks gestation
- First pregnancy (nulliparity)
- Own a cell phone
- Ability to read and write
- Residing in Tegucigalpa
- Good general health based on medical history
- Ultrasound showing amniotic fluid index greater than 5 cm
- Non-stress test reactive
- Ability to take oral medication and follow cinnamon capsule regimen
You will not qualify if you...
- Current use of antihypertensive or hypoglycemic medications
- Chronic diseases before or during pregnancy such as hypertension, diabetes, or hypothyroidism
- Premature rupture of membranes
- Infections like urinary tract infection or chorioamnionitis at study time
- Allergies to cinnamaldehyde, cinnamon, or canola oil
- Multiple pregnancy
- Major fetal malformations
- Fetal death
- Non-cephalic fetal presentation
- Severe oligohydramnios with amniotic fluid index less than 2 cm
- Use of cinnamon products within 7 days before study
- Febrile illness within 7 days before starting cinnamon
- Treatment with other investigational drugs within 7 days before intervention
- Current smoker or tobacco user
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hospital Escuela
Tegucigalpa, Francisco Morazán Department, Honduras, 11101
Actively Recruiting
Research Team
R
Ricardo A. Gutierrez Ramirez, MD, MSc
CONTACT
Y
Yadira Diaz Tilguant, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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