Actively Recruiting
The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and Hypocalcaemia
Led by Tseung Kwan O Hospital, Hong Kong · Updated on 2024-07-09
100
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
Sponsors
T
Tseung Kwan O Hospital, Hong Kong
Lead Sponsor
U
United Christian Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Thyroidectomy is a standard procedure for benign and malignant pathologies of the thyroid gland. Each year, some 100 total thyroidectomies are performed in Kowloon East Cluster, Hospital Authority, Hong Kong. Total thyroidectomy is associated with voice dysfunction and temporary hypocalcaemia in up to 80% and 50%, respectively. Previous study from our institute showed a 3% rate of permanent vocal cord palsy and 16% of permanent hypoparathyroidism requiring calcium and/or vitamin D supplements. The use of dexamethasone has been studied in the past in total thyroidectomy patients and has been shown to be safe and effective in improving post-operative nausea and vomiting. No complications or drug related side effects were associated with a single dose of steroid. Recent studies have also shown that Dexamethasone is effective in improving voice outcome and hypocalcaemia in thyroidectomy patients. The investigators aim to study the effect of Dexamethasone in post-operative voice outcome and hypocalcaemia. Objective assessment of the vocal cords during phonation will be performed pre-operative and post-operatively. Serum Calcium level will be monitored.
CONDITIONS
Official Title
The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and Hypocalcaemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 or above
- Patients undergoing total thyroidectomy for benign pathologies
- Multinodular goitre (MNG)
- Toxic nodular goitre
- Graves' disease
You will not qualify if you...
- Non-communicable patients
- Patients contraindicated for steroid (diabetes mellitus, hepatitis carrier, tuberculosis, peptic ulcer disease)
- Patients contraindicated for analgesics including Panadol, Celebrex, Tramadol, or Levobupivacaine
- Malignant thyroid disease
- Patients with previous thyroid surgery or neck surgery
- Pre-existing hoarseness of voice of any cause or pre-existing vocal cord palsy
- Pregnancy or lactating female patients
- Pre-existing renal disease or autoimmune disease on steroids
- Patients who require steroid cover during operation (e.g., hydrocortisone perioperatively)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Otorhinolaryngology, Head and Neck Surgery, United Christian Hospital and Tseung Kwan O Hospital
Hong Kong, Hong Kong
Actively Recruiting
Research Team
C
Cherrie Ng
CONTACT
T
Thomas Hui, BSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here