Actively Recruiting
Led by University College, London · Updated on 2025-07-11
120
Participants Needed
1
Research Sites
4 weeks
Total Duration
U
University College, London
Lead Sponsor
R
Royal Free Hospital NHS Foundation Trust
Collaborating Sponsor
Researchers are studying chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease, bronchiectasis, and their connection with sleep-disordered breathing (SDB), including obstructive sleep apnoea. The goal is to compare patients with chronic respiratory diseases who have SDB to those who do not, using a new analytical method to better understand the underlying physiological differences. This study focuses on how breathing disturbances during sleep may worsen when chronic respiratory diseases coexist with SDB. The study will analyze sleep data by measuring changes in respiratory signals entropy, oxygen saturation, and heart rate. These measurements will be collected using cardiorespiratory polygraphy during a 1-hour daytime period and overnight sleep. The research explores the use of nonlinear methods like entropy to assess irregularities in physiological signals from simple devices, such as pulse oximeters, to potentially improve screening for sleep apnoea. Participants will be adults with chronic respiratory disease, with or without SDB, and some healthy controls with previously negative studies. They will undergo sleep studies using portable monitoring devices while researchers collect data on oxygen levels, heart rate, and breathing patterns. The main outcome is to observe changes in entropy and other signals during sleep. The study duration for outcome measurement is about 2 months, starting in April 2025 and ending in September 2026.
CONDITIONS
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 2 days
Participants undergo assessments using cardiorespiratory polygraphy and portable monitoring devices to record respiratory signals, oxygen saturation, and heart rate during daytime and overnight sleep.
1 daytime and 1 overnight monitoring session
Duration - 2 months
Participants are observed over a 2-month period to assess changes in physiological signals related to sleep-disordered breathing and chronic respiratory disease.
No additional visits; data collected remotely or during monitoring sessions
Total: 1 location
1
Royal Free hospital
London, United Kingdom, NW3 2QG
Actively Recruiting
N
Nawal Alotaibi
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Mohamed El Shayeb, Leigh-Ann Topfer, Tania Stafinski...
https://pubmed.ncbi.nlm.nih.gov/24218531Amar S Bhogal, Ali R Mani
https://pubmed.ncbi.nlm.nih.gov/28824451