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Use of 'Mechanical Power' as a Predictor of Increased Serum and Pulmonary Proinflammatory Cytokine Concentrations in Patients With Acute Hypoxemic Respiratory Failure: A Prospective Observational Study
Led by University of Roma La Sapienza · Updated on 2024-05-22
150
Participants Needed
1
Research Sites
217 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to report the proportion of patients with acute hypoxemic respiratory failyre (AHRF) undergoing mechanical ventilation who exceed 17 J/min of mechanical power (MP) and the difference in terms of proinflammatory cytokine concentration in blood samples and bronchoalveolar lavage. The main questions it aims to answer are: 1. Which is the proportion of patients who exceed 17 J/min of mechanical power (MP) during the first 72 hours of mechanical ventilation? 2. Is there a difference in terms of cytokine concentration in patients undergoing mechanical power \>17 J/min compared to \<17 J/min? Patients will be divided into two groups based on respiratory mechanics measurements: low MP group (average MP \<17 J/min) and high MP group (average MP ≥17 J/min). The researchers will collect blood and BAL samples and perform cytokine assays.
CONDITIONS
Official Title
Use of 'Mechanical Power' as a Predictor of Increased Serum and Pulmonary Proinflammatory Cytokine Concentrations in Patients With Acute Hypoxemic Respiratory Failure: A Prospective Observational Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with acute hypoxemic respiratory failure (P/F <300 mmHg) on invasive mechanical ventilation within 7 days from symptom onset
- Invasive mechanical ventilation for less than 6 hours
- Newly developed lung consolidation seen on chest imaging (X-ray or CT)
- Age 18 years or older
You will not qualify if you...
- Prior invasive mechanical ventilation during the same hospital stay
- Tracheostomy
- Severe anemia (hemoglobin less than 7 g/dL)
- Severe neutropenia
- Kidney failure or receiving renal replacement therapy
- Receiving noradrenaline dose over 0.5 mcg/kg/min
- Pregnancy
- Use of extracorporeal circulation (ECCO2R, ECMO)
- Life expectancy less than 24 hours as judged by the doctor
- Lack of consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Sapienza University of Rome
Roma, Italy, 00161
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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