Actively Recruiting
The Use of Propranolol in the Perioperative Period of Resectable Gastrointestinal Tumors
Led by Huashan Hospital · Updated on 2025-01-14
40
Participants Needed
1
Research Sites
125 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this study, perioperative propranolol β-blockade was administered to patients with surgically resectable primary gastrointestinal tumors to explore the safety, efficacy, and alleviation of perioperative psychological stress. At the same time, a multi-omics study was conducted using clinical samples to explore the activation of anti-tumor immune response and its mechanism.
CONDITIONS
Official Title
The Use of Propranolol in the Perioperative Period of Resectable Gastrointestinal Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Surgically resectable primary gastric cancer or colorectal cancer
- Age greater than 18 years and less than 65 years
- Negative pregnancy test for women of childbearing age
- ECOG performance status score of 2 or less
- Signed informed consent
- Resting blood pressure greater than 100/60 mmHg and heart rate greater than 60 beats per minute
You will not qualify if you...
- Pregnant or breastfeeding women, or women planning pregnancy within six months
- Patients with contraindications to propranolol including sinus node syndrome, sinus bradycardia (less than 60 bpm), or any degree of AV block
- Resting blood pressure less than 100/60 mmHg
- Untreated pheochromocytoma or thyroid disease
- Use of calcium channel blockers such as diltiazem, verapamil, nifedipine, or amlodipine
- Severe peripheral vascular disease
- Use of antiarrhythmic drugs like amiodarone, sotalol, or digoxin
- Renal insufficiency defined as creatinine clearance greater than 0.15 mmol/L
- Hepatic insufficiency with liver enzymes or bilirubin above specified limits
- Use of medications including colistin, digoxin, rizatriptan, cimetidine, hydralazine, guanethidine, or ergotamine
- History of major depressive episodes
- Surgery for gastrointestinal tumors within the previous six months
- Receiving neoadjuvant chemotherapy before planned surgery
- Use of anxiolytic drugs such as benzodiazepines or alpha-adrenergic agonists
- Use of selective or non-selective beta-adrenergic inhibitors within the last three months
- History of stroke
- Moderate or severe asthma requiring hospitalization or oral steroids
- Other reasons determined by the physician for exclusion
AI-Screening
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Trial Site Locations
Total: 1 location
1
Huashan Hospital, Fudan University
Shanghai, Shanghai Municipality, China, 200040
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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