Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06055517

Use of Pulsed Low-dose Rate Re-irradiation for Recurrent Glioma (PULSAR)

Led by Centro di Riferimento Oncologico - Aviano · Updated on 2023-09-26

29

Participants Needed

1

Research Sites

261 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Re-irradiation in gliomas is a therapeutic option at recurrence before of 2nd-line chemotherapy. The dose of re-irradiation with conventional fractionation is unfortunately limited by the risk of symptomatic radionecrosis that is significant for cumulative doses above 100 Gy. The use of unconventional low dose rate pulsed radiotherapy (pLDRT) can reduce the risk of radiotoxicity while taking advantage of the cellular hyper-radiosensitivity that occurs at low dose-rates. The present study therefore aims at evaluating whether the use of pLDRT in the re-irradiation of recurrences of gliomas allows maintaining a low risk of symptomatic radionecrosis even for cumulative doses greater than 100 Gy.

CONDITIONS

Official Title

Use of Pulsed Low-dose Rate Re-irradiation for Recurrent Glioma (PULSAR)

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 6518 years
  • Ability to provide informed consent for treatment
  • Diagnosis of cerebral glioma
  • Confirmation of disease recurrence or relapse by histology or imaging
  • Previous brain radiation therapy completed at least 6 months prior
  • Performance status of ECOG 0 to 2
Not Eligible

You will not qualify if you...

  • Refusal to undergo radiation treatment or absence of informed consent
  • Receiving chemotherapy at the same time
  • Presence of leptomeningeal spread or tumor in both cerebral hemispheres
  • Current pregnancy

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

IRCCS-Centro di Riferimento Oncologico (CRO) di Aviano

Aviano, Pordenone, Italy, 33081

Actively Recruiting

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Research Team

L

Lorenzo Vinante, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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