Actively Recruiting
The Use of Ultrasound Detection of Lipohypertrophy to Improve Glycemic Control
Led by University of British Columbia · Updated on 2026-05-01
100
Participants Needed
1
Research Sites
200 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Lipohypertrophy is swelling of the fatty tissue located below the skin ("subcutaneous tissue") where many patients with diabetes inject their insulin. Lipohypertrophy can sometimes be felt as firm swelling, lumps or small bumps near insulin injection sites. Previous studies have shown that injecting insulin into areas of lipohypertrophy can affect how insulin is absorbed, and can increase insulin requirements in patients. New data suggest that lipohypertrophy can be detected using ultrasound technology. The ultrasonographic presence of changes to the subcutaneous tissue without swelling that can be felt ("subclinical lipohypertrophy") and the effect of injecting insulin into these sites is unknown. 100 people will participate in the Phase 1 of this study. In the second phase of the study, 40 patients identified with subclinical lipohypertrophy in Phase 1 will be asked to participate in the randomized study using crossover design by checking your glucose levels.
CONDITIONS
Official Title
The Use of Ultrasound Detection of Lipohypertrophy to Improve Glycemic Control
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Type 1 or Type 2 diabetes mellitus
- Using at least one insulin injection daily or insulin pump treatment for at least 2 years
- Aged between 19 and 80 years
You will not qualify if you...
- Taking glucagon-like peptide-1 agonist or systemic glucocorticoid medications
- History of non-lipohypertrophic skin disease in the insulin injection area
- Not fluent in English without a translator
AI-Screening
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Trial Site Locations
Total: 1 location
1
Vancouver General Hospital Diabetes Centre
Vancouver, British Columbia, Canada, V5Z 1M9
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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