Actively Recruiting
Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU
Led by Hospital do Coracao · Updated on 2025-04-13
60
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Renal dysfunction is a frequent complication in patients admitted to intensive care units (ICUs), associated with high morbidity and mortality. Current therapeutic options to prevent this condition are limited and lack robust scientific evidence. This pilot study consists of a multicenter, blinded, randomized clinical trial, unprecedented in the literature to date, aiming to fill this knowledge gap and offer new therapeutic perspectives to improve renal outcomes in critically ill patients admitted to the ICU.
CONDITIONS
Official Title
Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (18 years or older)
- Admitted to intensive care units
- Predicted risk of acute kidney injury score of 5 or higher based on clinical and laboratory data at ICU admission
You will not qualify if you...
- More than 24 hours since admission to the ICU
- Current use of vasopressors at study entry
- Mean arterial pressure greater than 90 mmHg
- Hyponatremia (sodium less than 130 mmol/L)
- Severe traumatic brain injury with Glasgow Coma Scale less than 8
- Undergoing elective surgeries
- Chronic kidney disease on dialysis or acute kidney injury requiring or expected to require renal replacement therapy within 24 hours
- Suspected or confirmed acute mesenteric ischemia
- Expected death within 24 hours
- Medical team not committed to full treatment at inclusion
- Prior participation in this study
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Matheus Liguori Feliciano da Silva
São Paulo, São Paulo, Brazil, 03115-001
Actively Recruiting
Research Team
M
Matheus Silva
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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