Actively Recruiting
Usefulness of High Resolution Manometry in Constipation
Led by University Hospital, Rouen · Updated on 2026-02-06
76
Participants Needed
3
Research Sites
240 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Constipation is a frequent symptom that is reported by more than 10% of the general population. In a few case, constipation is resistant to medical standard care, including osmotic and stimulant laxatives. The diagnosis of colonic inertia may be suspected in these patients although diagnostic criteria for colonic inertia may vary from one country to another. In France, the diagnosis of colonic inertia is based on manometric study of the colorectal contractile activity using manometric probe. Using conventional manometric catheters, severe alteration of the colorectal motility is found in a very small subset of patients, who may later benefit from surgery. The recent use of high resolution manometric probe allowed to map more precisely colorectal motility, but whether these new parameters are relevant remains to be assessed. The aim of this study is to assess the diagnostic performance of a new high resolution manometric probe by comparing healthy volunteers to patients suspected of colonic inertia.
CONDITIONS
Official Title
Usefulness of High Resolution Manometry in Constipation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years
- Chronic constipation lasting more than 6 months
- Delayed colonic transit time greater than 100 hours
- Normal colonoscopy
- Constipation not improved by at least one osmotic and one stimulant laxative according to French guidelines
- Affiliated to French national healthcare insurance
You will not qualify if you...
- Colonic transit time less than 100 hours
- Distal constipation with stasis in the rectum
- Constipation of organic origin
- Recent constipation less than 6 months
- Constipation relieved by osmotic or stimulant laxatives
- Contraindications to high resolution manometry such as intestinal occlusion, coagulation disorders, contraindications to general anesthesia or colonoscopy
- Failure to perform colonoscopy previously
- Medication affecting colorectal motility including opioids
- Progressive inflammatory or neoplastic diseases
- History of major digestive surgery (except appendectomy or cholecystectomy)
- Conditions affecting digestive motility such as diabetes mellitus and scleroderma
- Cardiac diseases contraindicating vagal stimulation
- Significant digestive diseases for healthy volunteers
- Constipation with Kess score greater than 11/39 and colonic transit time 60 hours or more for healthy volunteers
AI-Screening
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Trial Site Locations
Total: 3 locations
1
CHU CAEN
Caen, France, 14033
Actively Recruiting
2
Chu Lille
Lille, France, 59037
Actively Recruiting
3
Rouen University Hospital
Rouen, France
Actively Recruiting
Research Team
G
Guillaume GOURCEROL, Pr
CONTACT
J
Julien BLOT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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