A Prospective Multicenter Study to Determine the Usefulness of Systematic 18-FDG-PET-TC for the Management of Invasive Fungal Infection (PETIFI Project)

What this Trial Is About

Researchers are investigating the value of using 18F-FDG PET-CT scans in managing invasive fungal infections (IFIs). This national multicenter prospective cohort study across 14 Spanish hospitals aims to see if PET-CT provides better detection and monitoring of IFIs compared to conventional imaging. The study focuses on improving diagnosis, staging, treatment monitoring, and prognosis for patients with fungemia or focal IFI. Participants will receive a systematic 18F-FDG PET-CT scan as part of their IFI evaluation. For fungemia patients, a follow-up PET-CT is done 2 weeks after the initial scan. For those with focal IFIs, additional scans occur at 2-4 weeks and 12 weeks after the first PET-CT. The scans help assess infection spread and response to treatment. The study collects comprehensive clinical, microbiological, and imaging data, comparing PET-CT results with standard care imaging. Patients will be monitored through medical history reviews, clinical tests, and imaging evaluations. Specialists will interpret PET-CT images locally and centrally to standardize findings. The team will assess how PET-CT influences disease staging, treatment decisions, and outcomes. Key measures include antifungal treatment duration and survival at 6 months. Patient progress is evaluated at 100 days and 6 months, including infection recurrence and continuation of cancer treatments if applicable.

Usefulness of PET-CT for Invasive Fungal Infection