Actively Recruiting
Usefulness of Post-Operative Radiotherapy in High-grade Cutaneous Squamous Cell Carcinoma: an Observational Study
Led by Fondazione IRCCS Policlinico San Matteo di Pavia · Updated on 2025-03-17
120
Participants Needed
1
Research Sites
263 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Post-operative radiotherapy (PORT) is currently considered as the second most important therapy to treat high-grade cutaneous squamous cell carcinoma. Nonetheless, only few studies evaluate its impact on recurrence rate and the major part of those ones do not include a proper control group of patients. Most recent guide lines from NCCN, Sidemast and British associations of dermatologists suggest clinicians to offer or consider PORT in selected patients but class nor level of evidence of those guide lines are provided. This project evaluates impact of post-operative radiotherapy on recurrence rate and overall survival by comparing two cohort of patients, the former who accepted PORT and the latter who, nonetheless its necessity, decided to not undergo it. The hypothesis which this project will answer concerns the effectiveness of post-operative radiotherapy in preventing local and regional recurrences. We expect a significant decrease of recurrence rate in patients who undergo this therapeutic option as compared to those with clinical indication but do not undergo PORT.
CONDITIONS
Official Title
Usefulness of Post-Operative Radiotherapy in High-grade Cutaneous Squamous Cell Carcinoma: an Observational Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of high-grade cutaneous squamous cell carcinoma
- Eligibility for post-operative radiotherapy
- Ability to be followed up for at least 24 months
You will not qualify if you...
- Missing clinical or histological data
- Inability to have proper follow-up
- Occurrence of intermediate events such as pregnancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Fondazione IRCCS Policlinico San Matteo, SC Dermatologia
Pavia, Pavia, Italy, 27100
Actively Recruiting
Research Team
C
Chiara Giorgini, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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