Actively Recruiting

Phase Not Applicable
Age: 18Years - 65Years
All Genders
NCT07552701

USG-Guided TAPA vs RIFB Block for Postoperative Analgesia in Laparoscopic Cholecystectomy

Led by Hitit University · Updated on 2026-04-27

70

Participants Needed

1

Research Sites

62 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Laparoscopic cholecystectomy (LC) can cause moderate-to-severe postoperative pain from visceral, referred shoulder, and incisional sources. Multimodal analgesia is recommended, but opioids carry significant side effects. Ultrasound-guided interfascial plane blocks offer a safe alternative. The Modified Thoracoabdominal Nerve Block through Perichondrial Approach (M-TAPA) blocks T5-T12 dermatomes, while the Recto-Intercostal Fascial Plane Block (RIFPB) provides sensory blockade across the upper anterolateral abdomen. This study compares the postoperative analgesic efficacy of bilateral M-TAPA versus bilateral RIFPB in patients undergoing LC.

CONDITIONS

Official Title

USG-Guided TAPA vs RIFB Block for Postoperative Analgesia in Laparoscopic Cholecystectomy

Who Can Participate

Age: 18Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18-65 years
  • ASA physical classification I-II
  • Body mass index (BMI) less than 35 kg/m8
  • Scheduled for elective laparoscopic cholecystectomy due to gallstones
  • Able to understand and use the Numeric Rating Scale for pain
  • Able to understand and use the Quality of Recovery-15 scale
  • Able to communicate in Turkish
  • Provided written informed consent
Not Eligible

You will not qualify if you...

  • Refusal to participate in the study
  • BMI greater than 35 kg/m8
  • ASA physical classification III-V
  • Age under 18 or over 65 years
  • Allergy to local anesthetics or study analgesics
  • Pregnancy or breastfeeding
  • Unable to understand or use the pain scoring or recovery scales
  • Unable to communicate in Turkish
  • Uncontrolled anxiety disorder
  • Alcohol or drug dependency
  • Neuromuscular or peripheral nerve disease
  • High-dose opioid use within 3 days before surgery
  • Widespread chronic pain
  • Diabetes mellitus
  • Liver or kidney failure
  • Blood clotting disorders or use of blood thinners
  • Infection at the injection site
  • Having a second surgery along with the laparoscopic cholecystectomy
  • Previous abdominal surgery or trauma
  • Conversion from laparoscopic to open surgery
  • Problems with the pain control device
  • Severe pain despite multimodal analgesia
  • Planned not to be taken off breathing tube after surgery
  • Surgery stopped before completion for any reason

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Hitit University

Çorum, Turkey (Türkiye), 19100

Actively Recruiting

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Research Team

H

Hakan Akel, MD

CONTACT

A

Alperen KISA, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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