Actively Recruiting
Using ctDNA to Detect Minimal Residual Disease After Lung Cancer Resection
Led by University Health Network, Toronto · Updated on 2024-12-06
360
Participants Needed
3
Research Sites
299 weeks
Total Duration
On this page
Sponsors
U
University Health Network, Toronto
Lead Sponsor
O
Ontario Institute for Cancer Research
Collaborating Sponsor
AI-Summary
What this Trial Is About
ctDNALung-Detect is an investigator-initiated single arm, multi-institution study designed to assess the ctDNA detection rate and its association with Relapse Free Survival (RFS) in operable stage T1-T4 (T3,T4 multifocal) N0M0 non-small cell lung cancer (NSCLC) patients.
CONDITIONS
Official Title
Using ctDNA to Detect Minimal Residual Disease After Lung Cancer Resection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Ability to provide written informed consent
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Diagnosed with T1-T4 (including T3, T4 multifocal) N0M0 non-small cell lung cancer planned for complete surgical resection
- Tumor size at least 1 cm with some solid component on imaging
- Availability of surgical tumor formalin-fixed, paraffin-embedded (FFPE) specimens for ctDNA analysis
You will not qualify if you...
- Prior radiation, surgery, or chemotherapy for the current diagnosis of non-small cell lung cancer
- Incomplete surgical resection
- Concurrent enrollment in a therapeutic study using drug or radiation therapy (observational or diagnostic studies allowed)
- Concurrent active malignancy or invasive malignancy within the previous 2 years (certain non-invasive malignancies excluded)
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
Michael Garron Hospital
Toronto, Ontario, Canada
Actively Recruiting
2
St. Joseph's Health Centre
Toronto, Ontario, Canada
Actively Recruiting
3
University Health Network
Toronto, Ontario, Canada
Actively Recruiting
Research Team
M
Mary Rabey
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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