Actively Recruiting
Using Dupilumab to Improve Circadian Function, Sleep and Pruritus in Children With Moderate/Severe Atopic Dermatitis
Led by Northwestern University · Updated on 2026-04-27
40
Participants Needed
1
Research Sites
146 weeks
Total Duration
On this page
Sponsors
N
Northwestern University
Lead Sponsor
R
Regeneron Pharmaceuticals
Collaborating Sponsor
AI-Summary
What this Trial Is About
Single center, prospective, Open label study of sleep, pruritus and circadian function pre/post 12-weeks of dupilumab treatment in children 6-17 years old
CONDITIONS
Official Title
Using Dupilumab to Improve Circadian Function, Sleep and Pruritus in Children With Moderate/Severe Atopic Dermatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 6 and 17 years at enrollment
- Moderate to severe chronic atopic dermatitis diagnosed by a pediatric dermatologist or allergist
- Atopic dermatitis severity score of moderate (3) or severe (4) at baseline
- PROMIS sleep disturbance T-score of 60 or higher (patient or parent-proxy for under 8 years old)
- Willingness and ability to comply with visits and procedures
- Stable use of inhaled corticosteroids, topical steroids, and antihistamines for at least 14 days before study start
You will not qualify if you...
- Poorly controlled asthma (Asthma Control Test score 19 or less)
- Sleep disturbance on 2 or more nights in the past week due to allergic rhinitis
- Use of medications that cause scratching
- Major medical conditions such as cancer
- Active sleep-affecting conditions like obstructive sleep apnea, restless leg syndrome, insomnia, narcolepsy, severe sleep disordered breathing, severe depression, COVID-19, or hives
- Applied topical steroids within 7 days before either sleep study visit
- Use of systemic immunosuppressants within 30 days before first sleep study
- Showered or used moisturizers within 12 hours before either sleep study visit
- Inability to communicate in English
- Contraindications to dupilumab including history of allergic reaction to it or its components
- Pregnancy
- Clinical blindness affecting circadian rhythm
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Lurie Children's Hospital/Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
D
Dermatology CTU
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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