Actively Recruiting
Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
Led by San Francisco Veterans Affairs Medical Center · Updated on 2024-08-02
45
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will improve understanding of the circuit alterations that underlie motivation and pleasure deficits in depression, and could also lead to the development of biologically-based markers of neurostimulation-based treatment response.
CONDITIONS
Official Title
Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years
- Normal or corrected-to-normal vision
- Diagnosis of major depressive disorder (MDD) by DSM-5 criteria
- Screened for TMS and MRI safety
- On a stable psychiatric medication regimen for more than 1 month
You will not qualify if you...
- Premorbid IQ less than 70
- Past or present neurological problems including seizures or head trauma with cognitive effects
- Loss of consciousness greater than 30 minutes or with neurological consequences
- Major medical conditions or physical impairments that prevent participation in EEG, TMS, or MRI
- Substance dependence within the past year or misuse within the past 3 months
- Failed urine toxicology on the day of neuroimaging
- Known claustrophobia
- Pregnancy
- Past or present diagnosis of schizophrenia spectrum or other psychotic disorders
- Past or present bipolar or related disorders
- Past or present MDD with psychotic features
- Past or present gambling disorder
- For healthy controls only: any DSM-5 psychiatric disorder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
San Francisco VA Medical Center
San Francisco, California, United States, 94121
Actively Recruiting
Research Team
J
Jason B Hemmerle, MBA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here