Actively Recruiting
Using Ex Vivo Tumoroids To Predict Immunotherapy Response In NSCLC
Led by Jun Zhang, MD, PhD · Updated on 2024-02-23
25
Participants Needed
2
Research Sites
236 weeks
Total Duration
On this page
Sponsors
J
Jun Zhang, MD, PhD
Lead Sponsor
N
Nilogen Oncosystems
Collaborating Sponsor
AI-Summary
What this Trial Is About
To test whether it is feasible to perform the 3D-EX functional predictive response bioassay in the context of patients with advanced/metastatic NSCLC receiving immune checkpoint inhibitors in the standard of care clinical setting.
CONDITIONS
Official Title
Using Ex Vivo Tumoroids To Predict Immunotherapy Response In NSCLC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to understand the study and provide written informed consent
- Diagnosis of advanced or metastatic NSCLC
- No prior immunotherapy treatment
- Male or female age 18 years or older
- ECOG performance status between 0 and 2
- Measurable disease according to RECIST 1.1
- Presence of a lesion suitable for safe biopsy with sufficient tissue (at least 3-4 cores with 20g or larger biopsy needle) to create tumoroids
- At least one target lesion available to evaluate treatment response
- Planned treatment with anti-PD-1/L1 with or without anti-CTLA-4 as standard care
- Adequate organ function as defined by standard of care
- Women of child-bearing potential and men with partners of child-bearing potential must agree to use contraception or abstain as recommended for immune checkpoint inhibitor treatment
You will not qualify if you...
- Incarcerated individuals
- Not competent to make medical decisions, noncommunicative, or noncompliant as judged by the investigator
AI-Screening
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Trial Site Locations
Total: 2 locations
1
The University of Kansas Cancer Center (KUCC)
Fairway, Kansas, United States, 66205
Actively Recruiting
2
The University of Kansas Cancer Center, Westwood Campus
Kansas City, Kansas, United States, 66205
Actively Recruiting
Research Team
D
Darlene Kocher
CONTACT
J
Jonathon Barnette
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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