Abnormal Vestibulo-Ocular Reflex Function Correlates with Balance and Gait Impairment in People with Multiple Sclerosis.
Marco Tramontano, Laura Casagrande Conti, Amaranta Soledad Orejel Bustos...
https://pubmed.ncbi.nlm.nih.gov/39311220Actively Recruiting
Led by I.R.C.C.S. Fondazione Santa Lucia · Updated on 2025-11-20
30
Participants Needed
1
Research Sites
52 weeks
Total Duration
Researchers are evaluating the use of the Glialia supplement in people diagnosed with Persistent Perceptual Postural Dizziness (PPPD). This pilot study involves 30 participants, including 20 PPPD patients who may or may not have had a previous COVID-19 infection, and 10 control participants who have recovered from COVID-19. The main goal is to compare neuroinflammation levels between PPPD patients and controls and to see if Glialia reduces neuroinflammation more than a placebo. The trial is triple-blind, meaning neither participants nor researchers know who receives which treatment. Participants are randomly assigned to one of three groups: PPPD patients receiving Glialia, PPPD patients receiving a placebo that looks identical to Glialia, and control participants who have recovered from COVID-19 and receive Glialia. All participants take two soluble sachets daily for 60 days. The Glialia supplement contains 700 mg of Palmitoylethanolamide (umPEA) with supportive ingredients. The placebo group receives a matching treatment without active ingredients. During the study, participants will be assessed at the start and after 60 days for neuroinflammation levels. Additional evaluations include gait quality, dizziness impact, brain fog, and personality traits. Researchers will monitor mental clarity, quality of life, balance, and neuroinflammation changes. The study provides all treatments at no cost and includes safety and outcome monitoring throughout the 60-day treatment period.
CONDITIONS
Using Glialia for Treating Persistent Perceptual Postural Dizziness
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 60 days
Participants take two soluble sachets daily of either the Glialia supplement or placebo for 60 days to evaluate effects on neuroinflammation, mental clarity, quality of life, balance, and gait quality.
1 baseline visit and 1 follow-up visit
Total: 1 location
1
Fondazione Santa Lucia IRCCS
Rome, RM, Italy, 00142
Actively Recruiting
I
Iole Indovina, PhD
D
Diego Piatti, PT
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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