Using Near-Infrared Light to Study Blood Flow and Oxygen Use in Peripheral Artery Disease An Observational Study of Muscle Oxygenation and Treatment Outcomes

What this Trial Is About

Researchers are studying peripheral artery disease PAD to better understand how blood flows and how oxygen is used in the lower limbs of affected individuals. The study aims to differentiate patients with oxygen delivery problems from those with mitochondrial dysfunction using a special technique called BB-NIR-DCS, and to see if this method can predict how patients respond to vascular treatments. This research is observational and involves both people with and without PAD to compare findings. Participants without PAD will complete study procedures up to two times once at the start and again after 1 to 2 months. Those diagnosed with PAD may undergo up to four visits including baseline, follow-ups at 1 to 2 weeks, 1 to 2 months, and 4 to 6 months. Each visit includes various assessments such as MRI scans to measure muscle oxygenation and blood flow, questionnaires about quality of life and walking ability, and physical performance tests like treadmill walking and a six-minute walk. All participants will provide informed consent before joining. During the study, researchers will collect health history, physical measurements, and activity data using wearable monitors and logs. The main outcomes measured include quality of life, ankle-brachial index, walking ability, steps taken, oxygen levels in leg muscles, body composition, and muscle size and quality. The study may ask participants to return for repeat procedures if needed to ensure good data quality. The total participation period can last up to about six months for those with PAD.

Using Near-Infrared Light to Better Understand Peripheral Artery Disease