Actively Recruiting
Using Near-Infrared Light to Better Understand Peripheral Artery Disease
Led by The University of Texas at Arlington · Updated on 2026-01-02
120
Participants Needed
2
Research Sites
165 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to better understand how blood flows and how oxygen is utilized in the lower limbs of people who suffer from peripheral artery disease. This study will also assess how these factors affect treatment outcomes. Specific aims include: Aim 1: Utilize BB-NIR-DCS to differentiate PAD patients experiencing primary oxygen delivery limitations from those suffering from mitochondrial dysfunction. Aim 2: Test the efficacy of BB-NIR-DCS at predicting individual responses to vascular intervention.
CONDITIONS
Official Title
Using Near-Infrared Light to Better Understand Peripheral Artery Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years or older
- Willing to participate under the conditions described in the informed consent form
- Eligible to sign the informed consent form
- Established diagnosis of peripheral artery disease confirmed by a physician
- Able to comply with study requirements
- Completed Aim 1 (for Aim 2 cases)
- Asymptomatic with no history or diagnosis of peripheral artery disease (for controls)
You will not qualify if you...
- Ankle-Brachial Index greater than 0.9 or less than 0.4 (for Aim 1 cases)
- Isolated disease in aorta or iliac vessels
- Unstable angina or myocardial infarction within past 12 months
- Orthopedic or other physical limitations preventing data collection
- Contraindications to MRI including pacemaker, bone growth or fusion stimulators, tissue expander, cochlear implants
- Unable to walk 10 feet
- Receiving continuous oxygen therapy
- Pregnancy
- Presence of permanent jewelry (screened by MRI safety form and operator)
- History of peripheral artery disease (for controls)
- Overt cardiovascular disease such as heart failure (for controls)
- Known pulmonary disease excluding mild asthma (for controls)
- Current tobacco use (for controls)
- Blood pressure over 150/90 mmHg at screening (for controls)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of Texas at Arlington
Arlington, Texas, United States, 76010
Actively Recruiting
2
University of Texas Arlington
Arlington, Texas, United States, 76019
Not Yet Recruiting
Research Team
M
Michael Nelson, PhD
CONTACT
R
Rajvi Shah, MPH
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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