Actively Recruiting
Using Nicotine to Reverse Age-related Auditory Processing Deficits
Led by University of California, Irvine · Updated on 2026-03-27
48
Participants Needed
1
Research Sites
230 weeks
Total Duration
On this page
Sponsors
U
University of California, Irvine
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety of patient populations and in healthy aging.
CONDITIONS
Official Title
Using Nicotine to Reverse Age-related Auditory Processing Deficits
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 18 and 85 years of age
- Non-smokers with a score of 0-2 on the Fagerstr�f6m index of smoking dependency
- Cognitive performance within two standard deviations of the CERAD mean
You will not qualify if you...
- Younger than 18 or older than 85 years of age
- Deafness or excessive hearing loss
- Smokers with a score between 3 and 10 on the Fagerstr�f6m index of smoking dependency
- History of psychiatric illness, neurological disorders, diabetes mellitus, renal failure, or cardiovascular disease
- Regular use of prescription medications (excluding oral contraceptives)
- Drug dependency
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hearing and Speech Lab
Irvine, California, United States, 92697
Actively Recruiting
Research Team
F
Fan-Gang Zeng
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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