Actively Recruiting
Using a Steroid Mouthwash to Prevent Mouth Sores During Chemotherapy
Led by Woman's · Updated on 2026-03-30
45
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if a steroid mouthwash (dexamethasone) can prevent mouth sores caused by chemotherapy in adults with cancer. The main questions it aims to answer are: Does using dexamethasone mouthwash before and during chemotherapy lower the chance of getting moderate to severe mouth sores? Can this approach reduce pain and improve comfort during chemotherapy? Researchers will compare patients using the mouthwash to a historical group of patients who received similar chemotherapy but did not use the mouthwash, to see if the mouthwash helps prevent mouth sores. Participants will: Use a steroid mouthwash (4 times daily) for up to 8 weeks during chemotherapy Complete a short weekly survey about mouth discomfort during infusion visits
CONDITIONS
Official Title
Using a Steroid Mouthwash to Prevent Mouth Sores During Chemotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years or older
- Confirmed cancer diagnosis
- Scheduled to receive or currently receiving chemotherapy associated with oral mucositis (e.g., anthracyclines and taxanes)
- Able to provide informed consent
- Able to follow study procedures
You will not qualify if you...
- Current tobacco use or use within the past 6 weeks
- HIV/AIDS diagnosis
- Gastrointestinal disorders such as Crohn's disease, ulcerative colitis, or celiac disease
- History of cold sores (herpes simplex virus)
- Oral shingles (herpes zoster) within the past 6 weeks
- Active oral infections at enrollment (e.g., candidiasis)
- Known allergy or sensitivity to dexamethasone
- Unable to self-administer or tolerate the mouthwash
- Enrolled in conflicting clinical trials
- Existing oral ulcers or mucositis at enrollment
- Pregnant
- Uncontrolled diabetes mellitus with HbA1c unknown or greater than 8% in the past 3 months despite therapy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Woman's Hospital
Baton Rouge, Louisiana, United States, 70817
Actively Recruiting
Research Team
J
Jaymes H Collins, PhD
CONTACT
E
Ericka Seidemann, MA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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