Using Text Messages to Support Oral Chemotherapy Adherence in Adolescents and Adults With Acute Lymphoblastic Leukemia and T-cell Lymphoblastic Lymphoma

What this Trial Is About

Researchers are evaluating the use of text message reminders to improve how well adolescents and adults with acute lymphoblastic leukemia ALL or T-cell lymphoblastic lymphoma stick to their oral chemotherapy treatments. This study includes a pilot phase to test if participants find the text messaging acceptable, followed by an efficacy phase comparing different intensities of text messaging to standard care. The study is conducted at a single center and sponsored by the University of Chicago. Participants in the pilot phase receive high-intensity daily text messages for 28 days and complete questionnaires about the interventions acceptability. In the efficacy phase, participants are assigned to either high-intensity daily texts for two treatment cycles, low-intensity weekly texts for the second cycle after no texts in the first cycle, or standard care with no texts during the first cycle. The goal is to see if high-intensity texts lead to better adherence to oral mercaptopurine and methotrexate during the first cycle. Throughout the study, participants complete adherence assessments and questionnaires. Researchers will measure adherence to oral chemotherapy after each treatment cycle, evaluate the feasibility of text messaging in the pilot phase, and explore how patient factors relate to adherence over one year. The total study duration extends through the treatment cycles with follow-up assessments up to one year after enrollment in the efficacy phase.

Using Text Messages to Improve Oral Chemotherapy for Adolescents and Adults With Acute Lymphoblastic Leukemia