Actively Recruiting
Using Xe MRI to Guide Radiation Therapy for Lung Cancer
Led by Sean Fain · Updated on 2026-01-02
15
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research study is to explore using MRI scans with xenon to better image lung function, how lung function changes after radiation therapy, and to guide radiation therapy away from parts of the lung that have good function. This project is foundational to performing additional studies to establish if novel MRI imaging can serve as a guidance tool for lung cancer radiation treatment.
CONDITIONS
Official Title
Using Xe MRI to Guide Radiation Therapy for Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years
- Willing and able to provide informed consent and follow study schedules
- Clinical diagnosis of lung cancer with planned treatment by stereotactic body radiation therapy
You will not qualify if you...
- Under 18 years old or incarcerated
- MRI contraindications based on screening questionnaire
- Pregnant or lactating
- Resting oxygen saturation below 90% on supplemental oxygen
- Respiratory infection within 30 days before treatment
- History of ventricular cardiac arrhythmia
- Cardiac arrest within the past year
- Prior radiation therapy to the lung
- Current cancer treatment with agents increasing risk of radiation pneumonitis, such as immunotherapy or chemotherapy
- Inability to fit into the 129Xe vest coil for MRI
- Unable to hold breath for 15 seconds
- Unlikely to comply with imaging instructions
- Medical or psychological conditions posing undue risk or interfering with protocol compliance
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Iowa
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
E
Eric Bruening
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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