Uterine Junctional Zone Evaluation Using 3D Ultrasound and Its Link to Major Pregnancy Complications in Assisted Reproductive Technology

What this Trial Is About

This research investigates the uterine junctional zone JZ, an internal layer of the uterus involved in placentation, and its connection to major obstetrical complications like pre-eclampsia, pre-term labor, and fetal growth restriction in women undergoing assisted reproductive technology ART such as IVF, ICSI, or frozen embryo transfer. The study aims to understand how structural and functional changes in the JZ before conception may relate to these pregnancy complications. The study uses three-dimensional 3D ultrasound to evaluate the JZ on the day of final oocyte maturation trigger or before starting luteal phase support for frozen embryo transfer. Measurements include the quality of JZ visualization, its thickness described as regular, irregular, or interrupted, and JZ volume calculated by subtracting endometrial volume. Ultrasound exams are standardized and performed transvaginally by the same operator. Participants will undergo a 3D ultrasound at a specific time during their ART cycle. Researchers will monitor for adverse obstetrical outcomes including pre-eclampsia, pre-term labor, and fetal growth restriction up to 40 weeks of pregnancy, as well as assess high-risk first trimester screening for pre-eclampsia at 12 weeks. The study will help relate JZ characteristics to pregnancy outcomes, with all ultrasound data collected and analyzed prospectively.

Uterine Junctional Zone and Its Relation to Adverse Obstetrical Outcomes in Assisted Reproductive Technology