Actively Recruiting
Uterine Microbiome in Recurrent Pregnancy Loss
Led by Mỹ Đức Hospital · Updated on 2025-09-25
100
Participants Needed
2
Research Sites
176 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The female genital tract microbiome may reflect female reproductive health and may be related to pregnancy outcomes. Disturbances in this microbiome may be associated with adverse reproductive outcomes. The investigators hypothesize that the endometrial and vaginal microbiome composition in women with a history of recurrent pregnancy loss are different, compared with those in normal fertile women.
CONDITIONS
Official Title
Uterine Microbiome in Recurrent Pregnancy Loss
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female aged 18 to 38 years
- Regular menstrual cycle lasting 25 to 35 days
- For recurrent pregnancy loss group: at least 2 pregnancy losses
- Couples with normal karyotype results for recurrent pregnancy loss group
- No conditions causing pregnancy loss such as antiphospholipid syndrome or abnormal thyroid function
- Agree to participate in the study
- For healthy control group: no history of pregnancy loss
- At least 1 live birth with youngest child at least 6 months old
- Agree to participate in the study
You will not qualify if you...
- Irregular menstrual cycle
- Uterine abnormalities such as adenomyosis, intrauterine adhesions, unicornuate/bicornuate/arcuate uterus, unremoved hydrosalpinx, endometrial polyp, or submucosal fibroid
- Use of intrauterine device within the last 3 months
- Use of antibiotics, vaginal pessary, or contraceptive pills within 2 weeks
- Sexual intercourse within 48 hours before sample collection
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
My Duc Hospital
Ho Chi Minh City, Ho Chi Minh City, Vietnam, 70000
Actively Recruiting
2
My Duc Phu Nhuan Hospital
Ho Chi Minh City, Ho Chi Minh City, Vietnam, 70000
Actively Recruiting
Research Team
N
Nam T Nguyen, MD
CONTACT
T
Tuong M Ho, MD, MCE
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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