Actively Recruiting
Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders
Led by University of Pennsylvania · Updated on 2026-05-11
15
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating conservative management for placenta accreta spectrum disorders (PAS), a serious condition that can cause significant health risks for mothers. The study focuses on a group of selected participants who want to preserve their uterus instead of undergoing the common preterm cesarean-hysterectomy surgery. This pilot study aims to explore a safer alternative by leaving the placenta inside the uterus after delivery and closely monitoring the outcomes. Participants will receive conservative management which includes the use of antibiotics and uterine artery embolization following delivery. The study does not involve hysterectomy; instead, it focuses on preserving the uterus. This is a single-arm study where all participants undergo the same approach and are monitored carefully during their hospital stay after delivery and with outpatient follow-up until their uterus is confirmed to be empty. During the study, participants will have regular evaluations to track important outcomes such as the rate of hysterectomy, infection (endometritis), coagulopathy, vaginal bleeding, and pelvic pain from delivery through one year postpartum. Monitoring includes inpatient observation and ongoing outpatient visits to ensure safety and to assess the effectiveness of this uterine preservation approach over time.
CONDITIONS
Brief Title
Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent is provided.
- Willingness to comply with all study procedures and be available for the study duration.
- Female person with a uterus, age 18 or older.
- Currently pregnant with an intrauterine gestation or postpartum.
- Suspected of having placenta accreta spectrum (PAS) based on history, clinical findings, or imaging.
- Usual management would be peripartum hysterectomy.
- Patient desires uterine preservation or declines hysterectomy.
- Agreement to adhere to lifestyle considerations during the study.
You will not qualify if you...
- Low antenatal suspicion for placenta accreta spectrum based on imaging.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Delivery through 1 year
Participants undergo conservative management at the time of caesarean section to preserve their uterus, including antibiotics and uterine artery embolization, followed by close monitoring.
Trial Site Locations
Total: 1 location
1
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
B
Beth Pineles, MD Phd
M
Meaghan McCabe, MPH
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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