Actively Recruiting
Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders
Led by University of Pennsylvania · Updated on 2026-05-11
15
Participants Needed
1
Research Sites
297 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study for the conservative management of placenta accreta spectrum disorders (PAS), which are a major cause of maternal morbidity and mortality. The most common management strategy for PAS in the United States is a preterm cesarean-hysterectomy. However, accumulating data show that conservative management is safer and is preferred by some patients. In selected participants (n=15) who desire uterine preservation, the investigators provide the option of conservative management, which will be defined as leaving the placenta in the uterus after delivery of the infant. This is a single-arm single-site pilot study where all participants will be carefully monitored during a standard postpartum inpatient stay and with outpatient follow-up until the uterus is empty.
CONDITIONS
Official Title
Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provide signed and dated informed consent.
- Willingness to comply with all study procedures and be available for the study duration.
- Female with a uterus, age 18 or older.
- Currently pregnant with an intrauterine pregnancy or postpartum.
- Suspected placenta accreta spectrum based on history, clinical findings, or imaging.
- Usual management would be peripartum hysterectomy.
- Desire to preserve the uterus or decline hysterectomy.
- Agree to follow lifestyle considerations during the study.
You will not qualify if you...
- Low antenatal suspicion for placenta accreta spectrum based on imaging.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
B
Beth Pineles, MD Phd
CONTACT
M
Meaghan McCabe, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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