Actively Recruiting
Uterine Transplant in Absolute Uterine Infertility (AUIF)
Led by Brigham and Women's Hospital · Updated on 2026-04-28
10
Participants Needed
1
Research Sites
87 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will examine the feasibility of initiating a uterine transplant program for Absolute Uterine Factor Infertility (AUFI) at Brigham and Women's Hospital. The investigators plan to screen 30 patients with a goal of enrolling 10 patients. (5 donors and 5 recipients) After careful screening, appropriate candidates will undergo IVF, Uterine Transplantation, Embryo Transfer, Pregnancy and Delivery. Once the uterus is explanted, five years of follow-up is planned.
CONDITIONS
Official Title
Uterine Transplant in Absolute Uterine Infertility (AUIF)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 40 years for recipients
- Clinical diagnosis of Absolute Uterine Factor Infertility (AUFI)
- Ability to produce at least 6 normal embryos by IVF
- Body Mass Index (BMI) less than 30
- Normal kidney function
- Ability to undergo transplant and follow treatment plan
- Stable partner and social support
- Partner willing to have psychological evaluation and recommended immunizations
- Stable home environment to support a child
- Donor age 40 to 60 years
- Donor has completed childbearing with previous full-term pregnancies
- Donor able to take estrogen-containing birth control pills
- Donor with BMI of 30 or less
- Donor has good social support
You will not qualify if you...
- Active smoking, alcohol use, or illicit drug use
- Inability to comply with treatment such as medication, biopsies, or appointments
- Medical conditions making pregnancy or immunosuppressive treatment too risky
- Active infections including HIV, Tuberculosis, Hepatitis B or C
- History of extensive abdominal or pelvic surgery
- History of abnormal Pap smear or genital warts
- History of pelvic inflammatory disease
- Donor psychiatric illness
- Donor cervical or uterine polyps or tumors
- Donor history of more than one Caesarian section
- Donor internal scarring from surgery
- Donor hypertension, coronary artery disease, COPD, or diabetes
- Donor active or incompletely treated cancer
- Donor history of blood clotting or bleeding disorders
- Donor evidence of coercion or exchange for organ donation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
S
Stefan G Tullius, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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