Different underlying neurocognitive deficits in developmental dyslexia: a comparative study.
D Menghini, A Finzi, M Benassi...
https://pubmed.ncbi.nlm.nih.gov/19909762Actively Recruiting
Phase Not Applicable
Age: 8Years - 13Years
All Genders
Healthy Volunteers
ID05972200
Probing the Efficacy of V5/MT Stimulation on Reading and Reading-related Measures in Children and Adolescents With Developmental Dyslexia
Led by Bambino Gesù Hospital and Research Institute · Updated on 2023-08-04
36
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to explore the effects of a brain stimulation technique called high-definition transcranial direct current stimulation (HD-tDCS) on reading skills in children and adolescents with developmental dyslexia (DD). Dyslexia is a neurodevelopmental disorder that affects reading ability and is linked to brain differences, particularly in visual and auditory pathways. The study will investigate how stimulating specific brain areas involved in visual processing, such as the left V5/MT region, may improve reading abilities. Participants will receive different types of HD-tDCS in a randomized order: active stimulation over the left V5/MT area, active stimulation over the left V1 area, or sham (placebo) stimulation over either area. Each stimulation session lasts 20 minutes with a current intensity of 1 mA using small electrodes placed on the scalp. The study will use a within-subject design, meaning each participant experiences all three stimulation conditions in different sequences. During the study, researchers will assess reading accuracy and speed using experimental reading tasks that measure text, word, and non-word reading, as well as other related skills like rapid naming and eye movements. Brain activity will also be monitored using EEG. The study tracks these outcomes during the stimulation procedures to understand the effects. The total participation period and follow-up details are based on the experimental sessions and assessments conducted during the study.
CONDITIONS
Brief Title
V5/MT Stimulation on Reading and Reading-related Measures in Developmental Dyslexia
Who Can Participate
Age: 8Years - 13Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Italian-speaking, right-handed children and adolescents diagnosed with dyslexia according to DSM-5
- Word, nonword, or text reading accuracy and/or speed at least 2 standard deviations below the mean for school-age
- Nonverbal IQ of 85 or higher
- Normal hearing and normal or corrected-to-normal vision
You will not qualify if you...
- Presence of other primary psychiatric or neurological diagnoses such as depression, anxiety, autism, or ADHD
- Personal history of neurological, medical, or genetic diseases
- Current drug treatment that influences brain function
- Epilepsy or family history of epilepsy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 3 treatment sessions with washout periods between sessions
Participants receive high-definition transcranial direct current stimulation (HD-tDCS) over targeted brain areas (V5/MT and V1) or sham stimulation in a crossover design to assess effects on reading and related cognitive measures.
3 stimulation visits (in-person)
Trial Site Locations
Total: 1 location
1
Bambino Gesù Hospital and Research Institute
Roma, Italy, 00165
Actively Recruiting
Loading map...
Research Team
D
Deny Menghini
G
Giulia Lazzaro
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
6
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Specific reading disability (dyslexia): what have we learned in the past four decades?
Frank R Vellutino, Jack M Fletcher, Margaret J Snowling...
https://pubmed.ncbi.nlm.nih.gov/14959801Phonological skills and their role in learning to read: a meta-analytic review.
Monica Melby-Lervåg, Solveig-Alma Halaas Lyster, Charles Hulme
https://pubmed.ncbi.nlm.nih.gov/22250824Clinical neurophysiology of visual and auditory processing in dyslexia: a review.
Gerd Schulte-Körne, Jennifer Bruder
https://pubmed.ncbi.nlm.nih.gov/20570212Dyslexia: a deficit in visuo-spatial attention, not in phonological processing.
Trichur R Vidyasagar, Kristen Pammer
https://pubmed.ncbi.nlm.nih.gov/20080053A causal link between visual spatial attention and reading acquisition.
Sandro Franceschini, Simone Gori, Milena Ruffino...
https://pubmed.ncbi.nlm.nih.gov/22483940Developmental dyslexia: the visual attention span deficit hypothesis.
Marie-Line Bosse, Marie Josèphe Tainturier, Sylviane Valdois
https://pubmed.ncbi.nlm.nih.gov/16859667Slow perceptual processing at the core of developmental dyslexia: a parameter-based assessment of visual attention.
Prisca Stenneken, Johanna Egetemeir, Gerd Schulte-Körne...
https://pubmed.ncbi.nlm.nih.gov/21903119The Role of Visual-Spatial Abilities in Dyslexia: Age Differences in Children's Reading?
Giulia Giovagnoli, Stefano Vicari, Serena Tomassetti...
https://pubmed.ncbi.nlm.nih.gov/28066311A perceptual learning deficit in Chinese developmental dyslexia as revealed by visual texture discrimination training.
Zhengke Wang, Alice Cheng-Lai, Yan Song...
https://pubmed.ncbi.nlm.nih.gov/24643918