Actively Recruiting
Vaccine Responses to SARS-CoV-2 and Other Emerging Infectious Diseases
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-05-08
1200
Participants Needed
1
Research Sites
1472 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Vaccines against SARS-CoV-2, the virus that causes COVID-19, have been highly effective against preventing severe disease. But the protective effects of these vaccines appear to wane over time. Researchers want to learn why. Objective: To learn more about how the immune system responds to vaccines against infections like SARS-CoV-2. Eligibility: Healthy adults ages 18 or older who are scheduled to receive either a new vaccine or a booster shot against SARS-COV-2 or another emerging infection. Design: Participants will be screened with a medical history and blood and urine tests. Participants will have up to 8 study visits in 1 year. Each visit should last less than 2 hours. At each visit, participants will give blood samples. Some blood samples will be used for genetic testing. They will also give updates on their health. After the first study visit, participants will receive either a first vaccination or a booster shot. They must get the vaccine in their community or workplace. They will not get the vaccine at NIH. This study currently focuses on SARS-CoV-2, but it will expand to other infectious diseases as they emerge and become the target of new vaccines. ...
CONDITIONS
Official Title
Vaccine Responses to SARS-CoV-2 and Other Emerging Infectious Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willingness to comply with all study procedures and availability for the duration of the study
- Age 18 years or older
- Hemoglobin level at least 9.0 g/dL, or at least 11.2 g/dL for pregnant women
- Willingness to consent to storage of blood samples for research
- Ability to understand and sign a written informed consent document
- For new vaccination group: no prior receipt of vaccine for the infectious disease being studied
- For booster vaccination group: willingness to return for baseline blood collection before booster shot
You will not qualify if you...
- Current abuse of alcohol or drugs that could interfere with study compliance
- Any medical or mental health condition that would prevent participation in the study as judged by the Principal Investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
C
Catherine A Seamon, R.N.
CONTACT
S
Susan L Moir, Ph.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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