Actively Recruiting
Vagal Stimulation Therapy and Preeclampsia
Led by Fundación Internacional René Mey · Updated on 2026-04-09
210
Participants Needed
4
Research Sites
58 weeks
Total Duration
On this page
Sponsors
F
Fundación Internacional René Mey
Lead Sponsor
C
Coordinación de Investigación en Salud, Mexico
Collaborating Sponsor
AI-Summary
What this Trial Is About
Preeclampsia is one of the most common and serious complications of pregnancy, affecting both the mother and baby. It is a condition characterized by high blood pressure and can lead to severe complications, including neurological issues and reduced blood flow to the placenta. Preeclampsia is responsible for a significant number of maternal and perinatal deaths worldwide, with an estimated 14% of maternal mortality in Mexico linked to this condition. Recent research suggests that disruptions in the body's autonomic nervous system, specifically the balance between the sympathetic and parasympathetic systems, play a role in the development of preeclampsia. The vagus nerve, which is part of the parasympathetic system, has been shown to regulate inflammation and blood pressure. Stimulating this nerve through pharmacological, magnetic, electrical, or physical therapy techniques has shown promise in preclinical models for improving blood pressure control and reducing complications associated with preeclampsia. Trigger point release therapy modulates the nervous system by reducing sympathetic activity, promoting blood vessel relaxation, lowering heart rate, and enhancing circulation. When combined with standard antihypertensive treatment, this approach may offer additional benefits for blood pressure regulation. This study aims to evaluate the effects of vagal autonomic stimulation physiotherapy using trigger point release therapy as a complementary treatment for pregnant women with preeclampsia. Participants will be randomly assigned to receive either standard antihypertensive treatment with positional release therapy (control group) or the same treatment combined with vagal stimulation physiotherapy (intervention group). Researchers will assess the intervention's effectiveness in controlling blood pressure and improving overall maternal and fetal health outcomes. By investigating this non-invasive, drug-free approach, this study aims to offer new strategies for managing preeclampsia, potentially improving maternal and fetal health while reducing reliance on medication.
CONDITIONS
Official Title
Vagal Stimulation Therapy and Preeclampsia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients over 18 years old
- Outpatient pregnant women attending their first obstetrics consultation at IMSS Jalisco
- Confirmed diagnosis of mild preeclampsia
- No prior antihypertensive treatment
- Willingness to participate by signing informed consent
You will not qualify if you...
- Chronic hypertension
- Concomitant organ dysfunction
- Immunological diseases
- Severe preeclampsia or chronic conditions complicating pregnancy
- Gestational trophoblastic disease requiring uterine evacuation or choriocarcinoma
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Unidad de Investigación Biomédica 02, UMAE HE CMNO IMSS
Guadalajara, Jalisco, Mexico, 44329
Not Yet Recruiting
2
Hospital General de Zona 110, IMSS
Guadalajara, Jalisco, Mexico, 44716
Actively Recruiting
3
Hospital General de Zona 46, IMSS
Guadalajara, Jalisco, Mexico, 44910
Not Yet Recruiting
4
Hospital General de Zona 180, IMSS
Tlajomulco de Zúñiga, Jalisco, Mexico, 45653
Not Yet Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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