Actively Recruiting
Is Valacyclovir Non-inferior to Valganciclovir as CMV and EBV Prophylaxis in Kidney Transplant Recipients? A Single-Center Prospective Randomized Pilot Study
Led by National Taiwan University Hospital · Updated on 2025-12-19
80
Participants Needed
1
Research Sites
261 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Opportunistic CMV viremia (primary infection or reactivation) is usually managed by taking prophylactic medication for both adult and pediatric kidney transplant patients. Most hospitals prescribe valganciclovir for this purpose but valacyclovir has also been used. The most unfavorable side effect of valganciclovir is bone marrow suppression which can be troublesome for kidney transplant patients who are already immunosuppressed. We aim to assess the non-inferiority of valacyclovir compared with valganciclovir in this study.
CONDITIONS
Official Title
Is Valacyclovir Non-inferior to Valganciclovir as CMV and EBV Prophylaxis in Kidney Transplant Recipients? A Single-Center Prospective Randomized Pilot Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age at least 3 years
- Received or about to receive kidney transplant within 2 weeks before screening
- Planned to receive antiviral prophylaxis against CMV and/or EBV as decided by transplant surgeon
- No active CMV or EBV infection detected by viral load test at screening
- Able and willing to provide informed consent and follow study procedures
You will not qualify if you...
- Severe health conditions that make participation unsafe as judged by transplant surgeon
- Pregnancy (valganciclovir may cause harm to unborn babies)
- Known allergy to both valacyclovir and valganciclovir
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital
Taipei, Taiwan
Actively Recruiting
Research Team
H
Hou-Xuan Huang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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