Actively Recruiting
Valacyclovir in Pain Management of Acute Apical Abscesses
Led by University of California, San Francisco · Updated on 2025-05-30
60
Participants Needed
1
Research Sites
114 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The Virus in Endodontics (VE) phase I pilot study for preoperative pain will be analyzed and adjusted for the Phase II clinical trial. The Phase II clinical trial on preoperative pain, postoperative pain, and clinical healing will involve 250 patients. Patients will be recruited from the same pool of participants as the Phase II clinical trial. Preoperative cone beam computed tomography (CBCT) scans will be taken as well as three and six month postoperative CBCT scans. The secondary outcomes form the Phase II randomized clinical trial will be clinical success and visible radiographic healing determined by CBCT images.
CONDITIONS
Official Title
Valacyclovir in Pain Management of Acute Apical Abscesses
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient must be 18 years or older
- Patient must be systemically healthy (ASA Class I or II)
- Patient must have clinical signs of pulp necrosis and acute apical abscess
- Patient must show radiographic evidence of apical disease on periapical radiography or cone-beam CT
- Patient must consent to receive conventional pulpal debridement or incision and drainage at study end
- Patient must have persistent moderate or higher pain (greater than 4 on 0-10 scale)
You will not qualify if you...
- Smoking more than 10 cigarettes per day
- Presence of external or internal tooth resorption
- Presence of marginal periodontitis
- Pregnancy or nursing
- Allergic or adverse reactions to amoxicillin or valacyclovir
- Teeth with unusual anatomy or inaccurate diagnosis on treatment day
- Currently taking antibiotics or antiviral medications
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UCSF Dental
San Francisco, California, United States, 94143
Actively Recruiting
Research Team
M
Mike Sabeti, DDS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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