Actively Recruiting
Validating IAAO for Muscle Outcomes
Led by University of Toronto · Updated on 2026-01-05
8
Participants Needed
1
Research Sites
24 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Consuming dietary protein stimulates whole-body and muscle protein synthesis, the latter of which is typically measured using invasive primed constant infusions of stable isotopes with concurrent muscle biopsies. Alternative non-invasive methodologies have been developed (namely the indicator amino acid oxidation (IAAO) technique) to estimate the impact of protein ingestion on whole-body protein synthesis as a proxy for determining dietary protein requirements. Given that the IAAO technique is based on principles of protein metabolism which occur in the liver, it is unclear how representative the IAAO outcomes of whole-body protein synthesis is to skeletal muscle protein synthesis. Validation of the IAAO technique against gold-standard, biopsy-derived measures of muscle metabolism (i.e., muscle protein synthesis) would assist in mitigating the invasiveness of muscle physiology and nutrition research.
CONDITIONS
Official Title
Validating IAAO for Muscle Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants will be aged 18-35 years old
- Participants will have a BMI within the normal range (18.5-24.9) and waist-to-hip ratio <0.95 for males and <0.8 for females
- Participants are willing to comply with study rules, including abstaining from extra physical activity 48 hours before session 4
- Female participants must have a self-reported regular menstrual cycle (25-35 days) within the last 3 months
- Participants must have a physical activity score of 24 or higher as measured by the Godin leisure time exercise questionnaire
You will not qualify if you...
- Inability to follow study compliance rules as judged by the principal investigator
- Regular tobacco or illicit drug use, including growth hormone or testosterone
- Current use of hormonal contraceptives
- History of allergy to local anesthetics such as lidocaine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Kinesiology & Physical Education
Toronto, Ontario, Canada, M5S 2C9
Actively Recruiting
Research Team
S
Sabrina T Barsky, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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