Study to Confirm Early Biomarkers Predicting Arm Movement Recovery After Stroke Using Brain Stimulation and MRI

What this Trial Is About

Researchers are investigating biomarkers related to upper arm motor recovery in people who have recently had an ischemic stroke, with the goal of improving future recovery treatments. This observational study aims to validate key biomarkers measured by transcranial magnetic stimulation TMS and MRI within days of stroke onset. It will also explore these biomarkers in cases of acute intracerebral hemorrhage, creating a large, multicenter dataset combining clinical, TMS, and MRI data. Participants include up to 657 stroke patients who undergo assessments during the acute stroke period. The study uses FDA-cleared TMS devices to measure motor evoked potentials MEP within the first week of hospitalization. MRI scans measure injury to motor pathways. The study validates the Predict Recovery Potential PREP-2 tool, which uses clinical and biomarker data to predict upper extremity outcomes at 90 days. Participants are assessed for motor impairment, function, and use of the affected arm. During the study, participants undergo evaluations including TMS and MRI within the first days after stroke, followed by clinical assessments of upper limb motor outcomes 90 days later. The main outcomes measured are the Upper Extremity-Fugl Meyer score and the Action Research Arm Test at 90 days post-stroke. Participants must be available for in-person visits and comply with all study procedures. The study collects comprehensive data to help improve prediction and treatment of arm recovery after stroke.

Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials