Actively Recruiting

Age: 18Years - 40Years
All Genders
NCT07155564

Validation of Energy Expenditure Measures Study

Led by University of Leipzig · Updated on 2026-04-30

34

Participants Needed

1

Research Sites

179 weeks

Total Duration

On this page

Sponsors

U

University of Leipzig

Lead Sponsor

H

Helmholtz Center Munich

Collaborating Sponsor

AI-Summary

What this Trial Is About

The energy that the human body burns and the amount of food consumed determine a person's body weight. If food intake covers the amount of energy burned, body weight remains constant - a state known as energy balance. Achieving an energy balance is not easy in everyday life. This is reflected in the increasing number of people suffering from morbid obesity. To counteract this development, it is important to have a better understanding of how much food a person should eat. In this study, the investigators will investigate the amount of food needed to meet a person's energy needs and bring them into energy balance. Primary aims of the study are i) to technically and biologically validate two whole-room indirect calorimeters (WRICs) and ii) by using whole-room indirect calorimetry, to achieve a more accurate estimate of a person's emergy balance compared to common approximation formulas. Secondary study aims: 1. To investigate whether the transfer of a person into energy balance using WRIC has an influence on energy expenditure measures compared to the transfer into energy balance using the usual approximation formula. 2. To investigate whether the transfer of a person into energy balance using WRIC has an influence on activity-dependent energy expenditure measures compared to the transfer into energy balance using the usual approximation formula. 3. To investigate whether differences in energy expenditure during energy balance during moderate and strenuous physical activity influence food intake. 4. To investigate whether energy intake in relation to energy expenditure during energy balance is related to weight development

CONDITIONS

Official Title

Validation of Energy Expenditure Measures Study

Who Can Participate

Age: 18Years - 40Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Ability to provide informed consent
  • Written declaration of consent
  • Healthy study participants
  • Able to perform moderate physical exercise using a bike ergometer
  • Women must use continuous contraception or be in the follicular phase of their menstrual cycle
Not Eligible

You will not qualify if you...

  • Weight change greater than 5 kg or 5% of body weight in the last 3 months
  • Nicotine abuse or alcohol/drug abuse
  • Strenuous physical activity more than 1 hour per day in everyday life
  • Body mass index less than 18.5 kg/m² or 40 kg/m² and above
  • Chronic diseases affecting energy expenditure
  • Food allergy or intolerance, or vegan diet
  • Conditions preventing use of wearable accelerometers (e.g., silicone contact allergy)
  • Impaired fasting glucose, diabetes mellitus, or prediabetes
  • Pregnancy or breastfeeding
  • Claustrophobia
  • Refusal to communicate incidental findings

AI-Screening

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Trial Site Locations

Total: 1 location

1

Department of Internal Medicine, Clinic for Endocrinology, Nephrology and Rheumatology, University of Leipzig

Leipzig, Saxony, Germany, 04103

Actively Recruiting

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Research Team

S

Sascha Heinitz, MD

CONTACT

H

Haiko Schlögl, MD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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